The regulation of epithelial cells volume in norm and pathology
The ability to regulate volume in response to changes in intracellular and extracellular osmolarity is one of the fundamental cell functions. Cell volume changes stimulate a variety of intracellular signaling cascades that activate protective and adaptive mechanisms. In general, the regulation of vo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2018-01-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1023 |
| _version_ | 1797872897101922304 |
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| author | O. O. Ponomarchuk G. V. Маximov S. N. Оrlov |
| author_facet | O. O. Ponomarchuk G. V. Маximov S. N. Оrlov |
| author_sort | O. O. Ponomarchuk |
| collection | DOAJ |
| description | The ability to regulate volume in response to changes in intracellular and extracellular osmolarity is one of the fundamental cell functions. Cell volume changes stimulate a variety of intracellular signaling cascades that activate protective and adaptive mechanisms. In general, the regulation of volume occurs due to the transport of osmolytes, which results in the restoration of the intracellular water volume and the normalization of cellular functions. In this review we focused on the physiological significance of regulatory volume decrease (RVD) and regulatory volume increase (RVI) in response to fluctuations of extra- and intracellular osmolarity in the context of epithelial cells. |
| first_indexed | 2024-04-10T01:06:22Z |
| format | Article |
| id | doaj.art-692417e963924bcd922456eff22ae89e |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:06:22Z |
| publishDate | 2018-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-692417e963924bcd922456eff22ae89e2023-03-13T09:58:23ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842018-01-01164426010.20538/1682-0363-2017-4-42-60731The regulation of epithelial cells volume in norm and pathologyO. O. Ponomarchuk0G. V. Маximov1S. N. Оrlov2Московский государственный университет имени М.В. Ломоносова; Научно-исследовательский центр Монреальского университетаМосковский государственный университет имени М.В. ЛомоносоваМосковский государственный университет имени М.В. ЛомоносоваThe ability to regulate volume in response to changes in intracellular and extracellular osmolarity is one of the fundamental cell functions. Cell volume changes stimulate a variety of intracellular signaling cascades that activate protective and adaptive mechanisms. In general, the regulation of volume occurs due to the transport of osmolytes, which results in the restoration of the intracellular water volume and the normalization of cellular functions. In this review we focused on the physiological significance of regulatory volume decrease (RVD) and regulatory volume increase (RVI) in response to fluctuations of extra- and intracellular osmolarity in the context of epithelial cells.https://bulletin.ssmu.ru/jour/article/view/1023регуляция объемаэпителиальные клеткипролиферациямиграцияканцерогенез |
| spellingShingle | O. O. Ponomarchuk G. V. Маximov S. N. Оrlov The regulation of epithelial cells volume in norm and pathology Бюллетень сибирской медицины регуляция объема эпителиальные клетки пролиферация миграция канцерогенез |
| title | The regulation of epithelial cells volume in norm and pathology |
| title_full | The regulation of epithelial cells volume in norm and pathology |
| title_fullStr | The regulation of epithelial cells volume in norm and pathology |
| title_full_unstemmed | The regulation of epithelial cells volume in norm and pathology |
| title_short | The regulation of epithelial cells volume in norm and pathology |
| title_sort | regulation of epithelial cells volume in norm and pathology |
| topic | регуляция объема эпителиальные клетки пролиферация миграция канцерогенез |
| url | https://bulletin.ssmu.ru/jour/article/view/1023 |
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