Association between antibiotics and adverse oncological outcomes in patients receiving targeted or immune-based therapy for hepatocellular carcinoma

Association between antibiotics and adverse oncological outcomes in patients receiving targeted or immune-based therapy for hepatocellular carcinoma

Background & Aims: Immune checkpoint inhibitors (ICIs) alone or in combination with other ICIs or vascular endothelial growth factor pathway inhibitors are therapeutic options in unresectable/metastatic hepatocellular carcinoma (HCC). Whether antibiotic (ATB) exposure affects outcome remains...

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Bibliographic Details
Main Authors: David J. Pinato, Xiaoxue Li, Pallavi Mishra-Kalyani, Antonio D’Alessio, Claudia A.M. Fulgenzi, Bernhard Scheiner, Matthias Pinter, Guo Wei, Julie Schneider, Donna R. Rivera, Richard Pazdur, Marc R. Theoret, Sandra Casak, Steven Lemery, Lola Fashoyin-Aje, Alessio Cortellini, Lorraine Pelosof
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:JHEP Reports
Subjects:
Antibiotics
Cancer immunotherapy
Targeted therapy
Immune checkpoint inhibitors
Hepatocellular carcinoma
Gut microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923000782

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