Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities
Despite progress in oncotherapy, cancer is still among the deadliest diseases in the Western world, emphasizing the demand for novel treatment avenues. Cold physical plasma has shown antitumor activity in experimental models of, e.g., glioblastoma, colorectal cancer, breast carcinoma, osteosarcoma,...
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MDPI AG
2020-03-01
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Series: | Applied Sciences |
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Online Access: | https://www.mdpi.com/2076-3417/10/6/1944 |
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author | Julia Berner Christian Seebauer Sanjeev Kumar Sagwal Lars Boeckmann Steffen Emmert Hans-Robert Metelmann Sander Bekeschus |
author_facet | Julia Berner Christian Seebauer Sanjeev Kumar Sagwal Lars Boeckmann Steffen Emmert Hans-Robert Metelmann Sander Bekeschus |
author_sort | Julia Berner |
collection | DOAJ |
description | Despite progress in oncotherapy, cancer is still among the deadliest diseases in the Western world, emphasizing the demand for novel treatment avenues. Cold physical plasma has shown antitumor activity in experimental models of, e.g., glioblastoma, colorectal cancer, breast carcinoma, osteosarcoma, bladder cancer, and melanoma in vitro and in vivo. In addition, clinical case reports have demonstrated that physical plasma reduces the microbial contamination of severely infected tumor wounds and ulcerations, as is often seen with head and neck cancer patients. These antimicrobial and antitumor killing properties make physical plasma a promising tool for the treatment of head and neck cancer. Moreover, this type of cancer is easily accessible from the outside, facilitating the possibility of several rounds of topical gas plasma treatment of the same patient. Gas plasma treatment of head and neck cancer induces diverse effects via the deposition of a plethora of reactive oxygen and nitrogen species that mediate redox-biochemical processes, and ultimately, selective cancer cell death. The main advantage of medical gas plasma treatment in oncology is the lack of adverse events and significant side effects compared to other treatment modalities, such as surgical approaches, chemotherapeutics, and radiotherapy, making plasma treatment an attractive strategy for the adjuvant and palliative treatment of head and neck cancer. This review outlines the state of the art and progress in investigating physical plasma as a novel treatment modality in the therapy of head and neck squamous cell carcinoma. |
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institution | Directory Open Access Journal |
issn | 2076-3417 |
language | English |
last_indexed | 2024-04-14T00:23:45Z |
publishDate | 2020-03-01 |
publisher | MDPI AG |
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spelling | doaj.art-6929e8bb7e824c68841f2517159b75e32022-12-22T02:22:51ZengMDPI AGApplied Sciences2076-34172020-03-01106194410.3390/app10061944app10061944Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and OpportunitiesJulia Berner0Christian Seebauer1Sanjeev Kumar Sagwal2Lars Boeckmann3Steffen Emmert4Hans-Robert Metelmann5Sander Bekeschus6Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, GermanyDepartment of Oral and Maxillofacial Surgery, Plastic Surgery, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, GermanyZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, 17489 Greifswald, GermanyClinic and Polyclinic for Dermatology and Venereology, Rostock University Medical Center, Strempelstr. 13, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, Rostock University Medical Center, Strempelstr. 13, 18057 Rostock, GermanyDepartment of Oral and Maxillofacial Surgery, Plastic Surgery, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, GermanyZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str. 2, 17489 Greifswald, GermanyDespite progress in oncotherapy, cancer is still among the deadliest diseases in the Western world, emphasizing the demand for novel treatment avenues. Cold physical plasma has shown antitumor activity in experimental models of, e.g., glioblastoma, colorectal cancer, breast carcinoma, osteosarcoma, bladder cancer, and melanoma in vitro and in vivo. In addition, clinical case reports have demonstrated that physical plasma reduces the microbial contamination of severely infected tumor wounds and ulcerations, as is often seen with head and neck cancer patients. These antimicrobial and antitumor killing properties make physical plasma a promising tool for the treatment of head and neck cancer. Moreover, this type of cancer is easily accessible from the outside, facilitating the possibility of several rounds of topical gas plasma treatment of the same patient. Gas plasma treatment of head and neck cancer induces diverse effects via the deposition of a plethora of reactive oxygen and nitrogen species that mediate redox-biochemical processes, and ultimately, selective cancer cell death. The main advantage of medical gas plasma treatment in oncology is the lack of adverse events and significant side effects compared to other treatment modalities, such as surgical approaches, chemotherapeutics, and radiotherapy, making plasma treatment an attractive strategy for the adjuvant and palliative treatment of head and neck cancer. This review outlines the state of the art and progress in investigating physical plasma as a novel treatment modality in the therapy of head and neck squamous cell carcinoma.https://www.mdpi.com/2076-3417/10/6/1944kinpenhnsccplasma medicinereactive oxygen and nitrogen speciesrnsros |
spellingShingle | Julia Berner Christian Seebauer Sanjeev Kumar Sagwal Lars Boeckmann Steffen Emmert Hans-Robert Metelmann Sander Bekeschus Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities Applied Sciences kinpen hnscc plasma medicine reactive oxygen and nitrogen species rns ros |
title | Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities |
title_full | Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities |
title_fullStr | Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities |
title_full_unstemmed | Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities |
title_short | Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities |
title_sort | medical gas plasma treatment in head and neck cancer challenges and opportunities |
topic | kinpen hnscc plasma medicine reactive oxygen and nitrogen species rns ros |
url | https://www.mdpi.com/2076-3417/10/6/1944 |
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