Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review
Background: Famous synthetic pharmacophores like Filgotinib, Dapiprazole, and Trazodone have Triazolopyridine as their primary building element. It has become more well-known in medicinal chemistry, to which its broad-spectrum impact may be attributed. Objective: The derivatization of the triazolopy...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223006433 |
| _version_ | 1797690927859367936 |
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| author | Popat Mohite Deepali Nahar Rahul Pawara Taha Alqahtani Sayed M. Eldin Nabendu Mukherje Abdel Rahman Mohammad Said Al-Tawaha Rashid Iqbal Sami Bawazeer Iftikhar Ali |
| author_facet | Popat Mohite Deepali Nahar Rahul Pawara Taha Alqahtani Sayed M. Eldin Nabendu Mukherje Abdel Rahman Mohammad Said Al-Tawaha Rashid Iqbal Sami Bawazeer Iftikhar Ali |
| author_sort | Popat Mohite |
| collection | DOAJ |
| description | Background: Famous synthetic pharmacophores like Filgotinib, Dapiprazole, and Trazodone have Triazolopyridine as their primary building element. It has become more well-known in medicinal chemistry, to which its broad-spectrum impact may be attributed. Objective: The derivatization of the triazolopyridine molecule has been widely discussed in several scientific articles, focusing on its biological and pharmacological properties. As lead compounds for developing new drugs, many analogues of Triazolopyridine have been found. This article summarizes and discusses the literature surrounding the synthesis and biological evaluation of the triazolopyridine framework. Methods: Relevant keywords were used to identify relevant published literature from all relevant databases, including SciFinder, PubMed, and Google Scholar. Supplementary relevant literature bibliographies were also searched to locate linked reports. Results: Step-by-step explanations of the synthetic approaches to Triazolopyridine-based ring systems were found in the literature. All Triazolopyridine derivative's pharmacological activities were enumerated according to their targets, and a detailed structure–activity link was created. Conclusion: The current review highlights various synthetic techniques for fabricating the triazolopyridine framework and its uses across several medical chemistry fields. The wide range of biological effects of compounds with the triazolopyridine skeleton, including those that are antibacterial, antifungal, anticancer, anti-inflammatory, antitubercular, analgesic, anticancer, and antidepressant, make them crucial in the process of developing new drugs and so on. Despite extensive research, the structure-based drug design technique can create new, effective pharmacophores. |
| first_indexed | 2024-03-12T02:06:10Z |
| format | Article |
| id | doaj.art-692af1ed5e424a93be8743636a383584 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-03-12T02:06:10Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-692af1ed5e424a93be8743636a3835842023-09-07T04:43:41ZengElsevierArabian Journal of Chemistry1878-53522023-10-011610105181Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive reviewPopat Mohite0Deepali Nahar1Rahul Pawara2Taha Alqahtani3Sayed M. Eldin4Nabendu Mukherje5Abdel Rahman Mohammad Said Al-Tawaha6Rashid Iqbal7Sami Bawazeer8Iftikhar Ali9Department of Pharmaceutical Chemistry, St. John Institute of Pharmacy and Research, Palghar, Maharashtra, IndiaDepartment of Pharmaceutical Chemistry, St. John Institute of Pharmacy and Research, Palghar, Maharashtra, IndiaR.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, IndiaDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaCenter of Research, Faculty of Engineering, Future University in Egypt, New Cairo 11835, EgyptDepartment of Health Sciences, Novel Global Community and Educational Foundation, Haebersham, AustraliaDepartment of Biological Sciences, Al Hussein Bin Talal University Ma’an, P.O. Box 20, JordanDepartment of Agronomy, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur 63100, PakistanUmm Al-Qura University, Faculty of Pharmacy, Department of Pharmacognosy, Makkah, Saudi ArabiaSchool of Life Sciences & Center of Novel Biomaterials, The Chinese University of Hong Kong, Shatin, Hong Kong; Centre for Plant Science and Biodiversity, University of Swat, Charbagh, Pakistan; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Corresponding author.Background: Famous synthetic pharmacophores like Filgotinib, Dapiprazole, and Trazodone have Triazolopyridine as their primary building element. It has become more well-known in medicinal chemistry, to which its broad-spectrum impact may be attributed. Objective: The derivatization of the triazolopyridine molecule has been widely discussed in several scientific articles, focusing on its biological and pharmacological properties. As lead compounds for developing new drugs, many analogues of Triazolopyridine have been found. This article summarizes and discusses the literature surrounding the synthesis and biological evaluation of the triazolopyridine framework. Methods: Relevant keywords were used to identify relevant published literature from all relevant databases, including SciFinder, PubMed, and Google Scholar. Supplementary relevant literature bibliographies were also searched to locate linked reports. Results: Step-by-step explanations of the synthetic approaches to Triazolopyridine-based ring systems were found in the literature. All Triazolopyridine derivative's pharmacological activities were enumerated according to their targets, and a detailed structure–activity link was created. Conclusion: The current review highlights various synthetic techniques for fabricating the triazolopyridine framework and its uses across several medical chemistry fields. The wide range of biological effects of compounds with the triazolopyridine skeleton, including those that are antibacterial, antifungal, anticancer, anti-inflammatory, antitubercular, analgesic, anticancer, and antidepressant, make them crucial in the process of developing new drugs and so on. Despite extensive research, the structure-based drug design technique can create new, effective pharmacophores.http://www.sciencedirect.com/science/article/pii/S1878535223006433Triazolopyridine1,2,3-triazolesBiological activities1,2,4-triazolesSynthesis |
| spellingShingle | Popat Mohite Deepali Nahar Rahul Pawara Taha Alqahtani Sayed M. Eldin Nabendu Mukherje Abdel Rahman Mohammad Said Al-Tawaha Rashid Iqbal Sami Bawazeer Iftikhar Ali Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review Arabian Journal of Chemistry Triazolopyridine 1,2,3-triazoles Biological activities 1,2,4-triazoles Synthesis |
| title | Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review |
| title_full | Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review |
| title_fullStr | Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review |
| title_full_unstemmed | Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review |
| title_short | Triazolopyridine, a leitmotif of synthetic methods and pharmacological attributes: An extensive review |
| title_sort | triazolopyridine a leitmotif of synthetic methods and pharmacological attributes an extensive review |
| topic | Triazolopyridine 1,2,3-triazoles Biological activities 1,2,4-triazoles Synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223006433 |
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