Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment
Abstract Early in the COVID-19 pandemic, it emerged that the risk of severe outcomes was greater in patients with co-morbidities, including cancer. The huge effort undertaken to fight the pandemic, affects the management of cancer care, influencing their outcome. Despite the high fatality rate of CO...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
|
| Series: | Journal of Translational Medicine |
| Online Access: | https://doi.org/10.1186/s12967-023-04110-w |
| _version_ | 1827961103309602816 |
|---|---|
| author | Concetta Meo Giuseppe Palma Francesca Bruzzese Alfredo Budillon Claudio Napoli Filomena de Nigris |
| author_facet | Concetta Meo Giuseppe Palma Francesca Bruzzese Alfredo Budillon Claudio Napoli Filomena de Nigris |
| author_sort | Concetta Meo |
| collection | DOAJ |
| description | Abstract Early in the COVID-19 pandemic, it emerged that the risk of severe outcomes was greater in patients with co-morbidities, including cancer. The huge effort undertaken to fight the pandemic, affects the management of cancer care, influencing their outcome. Despite the high fatality rate of COVID-19 disease in cancer patients, rare cases of temporary or prolonged clinical remission from cancers after SARS-CoV-2 infection have been reported. We have reviewed sixteen case reports of COVID-19 disease with spontaneous cancer reduction of progression. Fourteen cases of remission following viral infections and two after anti-SARS-CoV-2 vaccination. The immune response to COVID-19, may be implicated in both tumor regression, and progression. Specifically, we discuss potential mechanisms which include oncolytic and priming hypotheses, that may have contributed to the cancer regression in these cases and could be useful for future options in cancer treatment. |
| first_indexed | 2024-04-09T16:21:33Z |
| format | Article |
| id | doaj.art-692b51aa054246c299fee39169d6aa80 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-09T16:21:33Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-692b51aa054246c299fee39169d6aa802023-04-23T11:26:42ZengBMCJournal of Translational Medicine1479-58762023-04-0121111310.1186/s12967-023-04110-wSpontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatmentConcetta Meo0Giuseppe Palma1Francesca Bruzzese2Alfredo Budillon3Claudio Napoli4Filomena de Nigris5Department of Precision Medicine, School of Medicine, University of Campania “Luigi Vanvitelli”S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori - IRCCS - Fondazione G. PascaleS.S.D. Sperimentazione Animale, Istituto Nazionale Tumori - IRCCS - Fondazione G. PascaleScientific Directorate - National Institute of Cancer - IRCCS - Fondazione G. PascaleClinical Department of Internal Medicine and Specialistic Units, Division of Clinical Immunology and Immunohematology, Transfusion Medicine, and Transplant Immunology (SIMT), Azienda Universitaria Policlinico (AOU)Department of Precision Medicine, School of Medicine, University of Campania “Luigi Vanvitelli”Abstract Early in the COVID-19 pandemic, it emerged that the risk of severe outcomes was greater in patients with co-morbidities, including cancer. The huge effort undertaken to fight the pandemic, affects the management of cancer care, influencing their outcome. Despite the high fatality rate of COVID-19 disease in cancer patients, rare cases of temporary or prolonged clinical remission from cancers after SARS-CoV-2 infection have been reported. We have reviewed sixteen case reports of COVID-19 disease with spontaneous cancer reduction of progression. Fourteen cases of remission following viral infections and two after anti-SARS-CoV-2 vaccination. The immune response to COVID-19, may be implicated in both tumor regression, and progression. Specifically, we discuss potential mechanisms which include oncolytic and priming hypotheses, that may have contributed to the cancer regression in these cases and could be useful for future options in cancer treatment.https://doi.org/10.1186/s12967-023-04110-w |
| spellingShingle | Concetta Meo Giuseppe Palma Francesca Bruzzese Alfredo Budillon Claudio Napoli Filomena de Nigris Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment Journal of Translational Medicine |
| title | Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment |
| title_full | Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment |
| title_fullStr | Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment |
| title_full_unstemmed | Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment |
| title_short | Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment |
| title_sort | spontaneous cancer remission after covid 19 insights from the pandemic and their relevance for cancer treatment |
| url | https://doi.org/10.1186/s12967-023-04110-w |
| work_keys_str_mv | AT concettameo spontaneouscancerremissionaftercovid19insightsfromthepandemicandtheirrelevanceforcancertreatment AT giuseppepalma spontaneouscancerremissionaftercovid19insightsfromthepandemicandtheirrelevanceforcancertreatment AT francescabruzzese spontaneouscancerremissionaftercovid19insightsfromthepandemicandtheirrelevanceforcancertreatment AT alfredobudillon spontaneouscancerremissionaftercovid19insightsfromthepandemicandtheirrelevanceforcancertreatment AT claudionapoli spontaneouscancerremissionaftercovid19insightsfromthepandemicandtheirrelevanceforcancertreatment AT filomenadenigris spontaneouscancerremissionaftercovid19insightsfromthepandemicandtheirrelevanceforcancertreatment |