A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron)
<b>Background:</b> Obesity is associated with increased all-cause mortality and cardiovascular disease (CVD). An electrocardiogram (ECG) may be used to screen for subtle signs of CVD or altered cardiac morphology in the obese. <b>Methodology:</b> This observational cross-sect...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Medical Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3271/10/4/56 |
| _version_ | 1797456391934312448 |
|---|---|
| author | Aditya John Binu Sirish Chandra Srinath Kripa Elizabeth Cherian John Roshan Jacob Thomas V. Paul Nitin Kapoor |
| author_facet | Aditya John Binu Sirish Chandra Srinath Kripa Elizabeth Cherian John Roshan Jacob Thomas V. Paul Nitin Kapoor |
| author_sort | Aditya John Binu |
| collection | DOAJ |
| description | <b>Background:</b> Obesity is associated with increased all-cause mortality and cardiovascular disease (CVD). An electrocardiogram (ECG) may be used to screen for subtle signs of CVD or altered cardiac morphology in the obese. <b>Methodology:</b> This observational cross-sectional analysed ECG changes in patients with obesity at a tertiary care centre in southern India. <b>Results:</b> One hundred and fifty adult patients with a mean (SD) BMI of 39.9 (6.7) kg/m<sup>2</sup> were recruited in the study after excluding those with comorbidities (diabetes mellitus, systemic hypertension) or on chronic medications (ACE inhibitors). The cohort showed a female predominance (69.3%), with a mean (SD) age of 45.4 (11.2) years. Most patients exhibited a sinus rhythm (78%), with one patient showing features of first-degree conduction block. Sinus tachycardia was seen in 32 (21.3%) patients. We observed left and right ventricular hypertrophy in five (3.3%) and three (2%) patients, respectively. Observed ECG patterns included a prolonged QTc in 16 (10.7%) patients, inverted T-waves (mostly in the inferior leads) in 39 (26%) patients and ST-segment depression (predominantly in the lateral leads) in 14 (9.3%) patients. A greater prevalence was noted for morbid obesity. No deaths were reported in our cohort. <b>Conclusions:</b> The predominant ECG variations in this cohort included tachycardia, atrial enlargement, ventricular hypertrophy, conduction defects, LAD, features of ischemia or old infarction and repolarization abnormalities, with a greater prevalence in morbid obesity. Further studies are needed to assess the impact of weight reducing measures on reversibility of these changes and determine the association with outcomes in obese patients. |
| first_indexed | 2024-03-09T16:07:25Z |
| format | Article |
| id | doaj.art-692d616450b744fb8333de1b6b5861cc |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-03-09T16:07:25Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-692d616450b744fb8333de1b6b5861cc2023-11-24T16:34:26ZengMDPI AGMedical Sciences2076-32712022-09-011045610.3390/medsci10040056A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron)Aditya John Binu0Sirish Chandra Srinath1Kripa Elizabeth Cherian2John Roshan Jacob3Thomas V. Paul4Nitin Kapoor5Christian Medical College & Hospital, Vellore 632004, IndiaChristian Medical College & Hospital, Vellore 632004, IndiaChristian Medical College & Hospital, Vellore 632004, IndiaChristian Medical College & Hospital, Vellore 632004, IndiaChristian Medical College & Hospital, Vellore 632004, IndiaChristian Medical College & Hospital, Vellore 632004, India<b>Background:</b> Obesity is associated with increased all-cause mortality and cardiovascular disease (CVD). An electrocardiogram (ECG) may be used to screen for subtle signs of CVD or altered cardiac morphology in the obese. <b>Methodology:</b> This observational cross-sectional analysed ECG changes in patients with obesity at a tertiary care centre in southern India. <b>Results:</b> One hundred and fifty adult patients with a mean (SD) BMI of 39.9 (6.7) kg/m<sup>2</sup> were recruited in the study after excluding those with comorbidities (diabetes mellitus, systemic hypertension) or on chronic medications (ACE inhibitors). The cohort showed a female predominance (69.3%), with a mean (SD) age of 45.4 (11.2) years. Most patients exhibited a sinus rhythm (78%), with one patient showing features of first-degree conduction block. Sinus tachycardia was seen in 32 (21.3%) patients. We observed left and right ventricular hypertrophy in five (3.3%) and three (2%) patients, respectively. Observed ECG patterns included a prolonged QTc in 16 (10.7%) patients, inverted T-waves (mostly in the inferior leads) in 39 (26%) patients and ST-segment depression (predominantly in the lateral leads) in 14 (9.3%) patients. A greater prevalence was noted for morbid obesity. No deaths were reported in our cohort. <b>Conclusions:</b> The predominant ECG variations in this cohort included tachycardia, atrial enlargement, ventricular hypertrophy, conduction defects, LAD, features of ischemia or old infarction and repolarization abnormalities, with a greater prevalence in morbid obesity. Further studies are needed to assess the impact of weight reducing measures on reversibility of these changes and determine the association with outcomes in obese patients.https://www.mdpi.com/2076-3271/10/4/56obesityECGcardiovascular disease |
| spellingShingle | Aditya John Binu Sirish Chandra Srinath Kripa Elizabeth Cherian John Roshan Jacob Thomas V. Paul Nitin Kapoor A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron) Medical Sciences obesity ECG cardiovascular disease |
| title | A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron) |
| title_full | A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron) |
| title_fullStr | A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron) |
| title_full_unstemmed | A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron) |
| title_short | A Pilot Study of Electrocardiographic Features in Patients with Obesity from a Tertiary Care Centre in Southern India (Electron) |
| title_sort | pilot study of electrocardiographic features in patients with obesity from a tertiary care centre in southern india electron |
| topic | obesity ECG cardiovascular disease |
| url | https://www.mdpi.com/2076-3271/10/4/56 |
| work_keys_str_mv | AT adityajohnbinu apilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT sirishchandrasrinath apilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT kripaelizabethcherian apilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT johnroshanjacob apilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT thomasvpaul apilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT nitinkapoor apilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT adityajohnbinu pilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT sirishchandrasrinath pilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT kripaelizabethcherian pilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT johnroshanjacob pilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT thomasvpaul pilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron AT nitinkapoor pilotstudyofelectrocardiographicfeaturesinpatientswithobesityfromatertiarycarecentreinsouthernindiaelectron |