Intravaginal administration of progesterone using a new technique for sustained drug release in goats
The objective of the present study was to develop and evaluate a sustained release vaginal progesterone (P4) capsule containing a mixture of mucoadhesive polymer and silicone fluid. Goats were administered a gelatin capsule containing 0.4 g of P4 mixed in silicone fluid and either a hydroxypropylmet...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Society for Reproduction and Development
2020-06-01
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| Series: | The Journal of Reproduction and Development |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jrd/66/5/66_2019-151/_pdf/-char/en |
| _version_ | 1797615308107677696 |
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| author | Natsumi ENDO Larasati Puji RAHAYU Takashi YAMAMURA Hitoshi TANAKA Tomomi TANAKA |
| author_facet | Natsumi ENDO Larasati Puji RAHAYU Takashi YAMAMURA Hitoshi TANAKA Tomomi TANAKA |
| author_sort | Natsumi ENDO |
| collection | DOAJ |
| description | The objective of the present study was to develop and evaluate a sustained release vaginal progesterone (P4) capsule containing a mixture of mucoadhesive polymer and silicone fluid. Goats were administered a gelatin capsule containing 0.4 g of P4 mixed in silicone fluid and either a hydroxypropylmethylcellulose (HM) or polyaclil starch (PA) base. The mean plasma P4 concentrations at 2 and 12 h after administration were significantly higher in goats treated with PA capsules than in those with HM capsules. The plasma P4 concentrations in goats treated with HM capsules increased and remained above 1.0 ng/ml for 96 h after administration, whereas the plasma P4 concentrations in goats treated with PA capsules remained above 1.0 ng/ml for only 24 h after administration. In the next experiment, an HM capsule was attached to a silicone device and inserted in the vagina for 10 days. The plasma P4 concentration remained similar to that of the natural luteal phase for 9 days. These results suggest that a mixture of mucoadhesive polymer and silicone fluid has the potential to be applied clinically as a sustained release base for estrus synchronization or hormonal therapy. |
| first_indexed | 2024-03-11T07:24:29Z |
| format | Article |
| id | doaj.art-692e61e2b9f64ef381d7d60265cbec6f |
| institution | Directory Open Access Journal |
| issn | 0916-8818 1348-4400 |
| language | English |
| last_indexed | 2024-03-11T07:24:29Z |
| publishDate | 2020-06-01 |
| publisher | The Society for Reproduction and Development |
| record_format | Article |
| series | The Journal of Reproduction and Development |
| spelling | doaj.art-692e61e2b9f64ef381d7d60265cbec6f2023-11-17T07:41:01ZengThe Society for Reproduction and DevelopmentThe Journal of Reproduction and Development0916-88181348-44002020-06-0166548949210.1262/jrd.2019-151jrdIntravaginal administration of progesterone using a new technique for sustained drug release in goatsNatsumi ENDO0Larasati Puji RAHAYU1Takashi YAMAMURA2Hitoshi TANAKA3Tomomi TANAKA4Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, JapanLaboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, JapanDivision of Animal Breeding and Reproduction Research, Institute of Livestock and Grassland Science, NARO, Ibaraki 305-0901, JapanTakechi Co., Ltd., Ehime 791-2143, JapanLaboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, JapanThe objective of the present study was to develop and evaluate a sustained release vaginal progesterone (P4) capsule containing a mixture of mucoadhesive polymer and silicone fluid. Goats were administered a gelatin capsule containing 0.4 g of P4 mixed in silicone fluid and either a hydroxypropylmethylcellulose (HM) or polyaclil starch (PA) base. The mean plasma P4 concentrations at 2 and 12 h after administration were significantly higher in goats treated with PA capsules than in those with HM capsules. The plasma P4 concentrations in goats treated with HM capsules increased and remained above 1.0 ng/ml for 96 h after administration, whereas the plasma P4 concentrations in goats treated with PA capsules remained above 1.0 ng/ml for only 24 h after administration. In the next experiment, an HM capsule was attached to a silicone device and inserted in the vagina for 10 days. The plasma P4 concentration remained similar to that of the natural luteal phase for 9 days. These results suggest that a mixture of mucoadhesive polymer and silicone fluid has the potential to be applied clinically as a sustained release base for estrus synchronization or hormonal therapy.https://www.jstage.jst.go.jp/article/jrd/66/5/66_2019-151/_pdf/-char/enintravaginal administrationmucoadhesive polymersprogesterone |
| spellingShingle | Natsumi ENDO Larasati Puji RAHAYU Takashi YAMAMURA Hitoshi TANAKA Tomomi TANAKA Intravaginal administration of progesterone using a new technique for sustained drug release in goats The Journal of Reproduction and Development intravaginal administration mucoadhesive polymers progesterone |
| title | Intravaginal administration of progesterone using a new technique for sustained drug release in goats |
| title_full | Intravaginal administration of progesterone using a new technique for sustained drug release in goats |
| title_fullStr | Intravaginal administration of progesterone using a new technique for sustained drug release in goats |
| title_full_unstemmed | Intravaginal administration of progesterone using a new technique for sustained drug release in goats |
| title_short | Intravaginal administration of progesterone using a new technique for sustained drug release in goats |
| title_sort | intravaginal administration of progesterone using a new technique for sustained drug release in goats |
| topic | intravaginal administration mucoadhesive polymers progesterone |
| url | https://www.jstage.jst.go.jp/article/jrd/66/5/66_2019-151/_pdf/-char/en |
| work_keys_str_mv | AT natsumiendo intravaginaladministrationofprogesteroneusinganewtechniqueforsustaineddrugreleaseingoats AT larasatipujirahayu intravaginaladministrationofprogesteroneusinganewtechniqueforsustaineddrugreleaseingoats AT takashiyamamura intravaginaladministrationofprogesteroneusinganewtechniqueforsustaineddrugreleaseingoats AT hitoshitanaka intravaginaladministrationofprogesteroneusinganewtechniqueforsustaineddrugreleaseingoats AT tomomitanaka intravaginaladministrationofprogesteroneusinganewtechniqueforsustaineddrugreleaseingoats |