Synthesis, anticancer evaluation, and molecular modeling study of new 2-(phenylamino)pyrazolo[1,5-a]pyrimidine analogues

Synthesis, anticancer evaluation, and molecular modeling study of new 2-(phenylamino)pyrazolo[1,5-a]pyrimidine analogues

The reaction of 3-amino-5-phenylaminopyrazoles 2 with 3-(dimethylamino) acrylonitrile derivatives resulted in a series of substituted pyrazolopyrimidine analogues 4 and 6. The DFT studies of the isolated compounds showed that the frontier molecular orbitals energy gap was close and in the 2.65–2.81 ...

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Bibliographic Details
Main Authors:	Omer A. Azher, Aisha Hossan, Rami A. Pashameah, Amerah Alsoliemy, Arwa Alharbi, Turki M. Habeebullah, Nashwa M. El-Metwaly
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Series:	Arabian Journal of Chemistry
Subjects:	3-aminopyrazoles Pyrazolopyrimidines Molecular modelling MCF-7 Molecular docking
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535222007535

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