Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

Summary: Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) play critical roles in tumorigenesis. However, the mechanisms underlying MDSC and TAM development and function remain unclear. In this study, we find that myeloid-specific activation of Notch/RBP-J signaling do...

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Bibliographic Details
Main Authors: Jun-Long Zhao, Yu-Chen Ye, Chun-Chen Gao, Liang Wang, Kai-Xi Ren, Ru Jiang, Si-Jun Hu, Shi-Qian Liang, Jian Bai, Jia-Long Liang, Peng-Fei Ma, Yi-Yang Hu, Ben-Chang Li, Yong-Zhan Nie, Yan Chen, Xiao-Fei Li, Wei Zhang, Hua Han, Hong-Yan Qin
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Cell Reports
Subjects:
notch signaling
MDSC
TAM
lactate
MCT2
c-Jun
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722001784

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