Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2006-02-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/4/1/9/ |
| _version_ | 1811301121667366912 |
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| author | Jun'ichi Kobayashi Kunimi Kikuchi Naohito Aoki Shinya Mitsuhashi Tadashi Okada Hiroshi Shima Takaaki Kubota Yusuke Wakuda |
| author_facet | Jun'ichi Kobayashi Kunimi Kikuchi Naohito Aoki Shinya Mitsuhashi Tadashi Okada Hiroshi Shima Takaaki Kubota Yusuke Wakuda |
| author_sort | Jun'ichi Kobayashi |
| collection | DOAJ |
| description | Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B). |
| first_indexed | 2024-04-13T07:03:15Z |
| format | Article |
| id | doaj.art-69313788837644529adee0b4295bac9a |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T07:03:15Z |
| publishDate | 2006-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-69313788837644529adee0b4295bac9a2022-12-22T02:57:04ZengMDPI AGMarine Drugs1660-33972006-02-014191410.3390/md401009Manzamenones Inhibit T-Cell Protein Tyrosine PhosphataseJun'ichi KobayashiKunimi KikuchiNaohito AokiShinya MitsuhashiTadashi OkadaHiroshi ShimaTakaaki KubotaYusuke WakudaAbstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).http://www.mdpi.com/1660-3397/4/1/9/Protein tyrosine phosphatasesTCPTPInhibitorsManzamenones |
| spellingShingle | Jun'ichi Kobayashi Kunimi Kikuchi Naohito Aoki Shinya Mitsuhashi Tadashi Okada Hiroshi Shima Takaaki Kubota Yusuke Wakuda Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase Marine Drugs Protein tyrosine phosphatases TCPTP Inhibitors Manzamenones |
| title | Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase |
| title_full | Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase |
| title_fullStr | Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase |
| title_full_unstemmed | Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase |
| title_short | Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase |
| title_sort | manzamenones inhibit t cell protein tyrosine phosphatase |
| topic | Protein tyrosine phosphatases TCPTP Inhibitors Manzamenones |
| url | http://www.mdpi.com/1660-3397/4/1/9/ |
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