Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than th...

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Bibliographic Details
Main Authors: Jun'ichi Kobayashi, Kunimi Kikuchi, Naohito Aoki, Shinya Mitsuhashi, Tadashi Okada, Hiroshi Shima, Takaaki Kubota, Yusuke Wakuda
Format: Article
Language:English
Published: MDPI AG 2006-02-01
Series:Marine Drugs
Subjects:
Protein tyrosine phosphatases
TCPTP
Inhibitors
Manzamenones
Online Access:http://www.mdpi.com/1660-3397/4/1/9/

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