Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report
Sarcoid Like Reaction (SLR) is a localized non-caseating epithelioid granulomatous reaction seen secondary to certain immunotherapies and malignancies. Invasive melanoma, while being associated with onset of sarcoidosis, has not shown to directly induce SLR in the literature. We present the case of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024004067 |
| _version_ | 1827360884339507200 |
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| author | Mohammed Ahsan Alex Ashkin David H. Lindner Vishal P. Patel Andrew Lipman |
| author_facet | Mohammed Ahsan Alex Ashkin David H. Lindner Vishal P. Patel Andrew Lipman |
| author_sort | Mohammed Ahsan |
| collection | DOAJ |
| description | Sarcoid Like Reaction (SLR) is a localized non-caseating epithelioid granulomatous reaction seen secondary to certain immunotherapies and malignancies. Invasive melanoma, while being associated with onset of sarcoidosis, has not shown to directly induce SLR in the literature. We present the case of a 68-year-old male with malignant melanoma, who was found to have SLR prior to starting immunotherapy, which worsened while on pembrolizumab. This case highlights the challenge of distinguishing between drug-induced SLR and melanoma-induced SLR, and the implications in terms of management. |
| first_indexed | 2024-03-08T06:54:55Z |
| format | Article |
| id | doaj.art-6934065760d6452cab6bdbc81eb998c2 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:54:55Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6934065760d6452cab6bdbc81eb998c22024-02-03T06:37:13ZengElsevierHeliyon2405-84402024-01-01102e24375Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case reportMohammed Ahsan0Alex Ashkin1David H. Lindner2Vishal P. Patel3Andrew Lipman4Naples Community Hospital, 311 9th St. N. Suite 300, Naples, FL, 34102-5804, USA; Corresponding author.Naples Community Hospital, 311 9th St. N. Suite 300, Naples, FL, 34102-5804, USANaples Community Hospital, 311 9th St N #304, Naples, FL 34102 Naples, FL, 34102-5804, USANaples Community Hospital, 1285 Creekside Blvd E, Naples, FL, 34109, USAMedical Oncology and Hematology, Florida Cancer Specialists & Research Institute, Naples West: 681 4th Avenue N, Naples, FL, 34102, USASarcoid Like Reaction (SLR) is a localized non-caseating epithelioid granulomatous reaction seen secondary to certain immunotherapies and malignancies. Invasive melanoma, while being associated with onset of sarcoidosis, has not shown to directly induce SLR in the literature. We present the case of a 68-year-old male with malignant melanoma, who was found to have SLR prior to starting immunotherapy, which worsened while on pembrolizumab. This case highlights the challenge of distinguishing between drug-induced SLR and melanoma-induced SLR, and the implications in terms of management.http://www.sciencedirect.com/science/article/pii/S2405844024004067Sarcoid-like reactionPembrolizumabSarcoidosisMelanomaCase report |
| spellingShingle | Mohammed Ahsan Alex Ashkin David H. Lindner Vishal P. Patel Andrew Lipman Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report Heliyon Sarcoid-like reaction Pembrolizumab Sarcoidosis Melanoma Case report |
| title | Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report |
| title_full | Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report |
| title_fullStr | Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report |
| title_full_unstemmed | Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report |
| title_short | Sarcoid-like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report |
| title_sort | sarcoid like reaction in malignant melanoma exacerbated with pembrolizumab therapy case report |
| topic | Sarcoid-like reaction Pembrolizumab Sarcoidosis Melanoma Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024004067 |
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