Selecting a randomization method for a multi-center clinical trial with stochastic recruitment considerations

Selecting a randomization method for a multi-center clinical trial with stochastic recruitment considerations

Abstract Background The design of a multi-center randomized controlled trial (RCT) involves multiple considerations, such as the choice of the sample size, the number of centers and their geographic location, the strategy for recruitment of study participants, amongst others. There are plenty of met...

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Bibliographic Details
Main Authors: Oleksandr Sverdlov, Yevgen Ryeznik, Volodymyr Anisimov, Olga M. Kuznetsova, Ruth Knight, Kerstine Carter, Sonja Drescher, Wenle Zhao
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Medical Research Methodology
Subjects:
Multi-center clinical trial
Maximum tolerated imbalance
Allocation randomness
Poisson-gamma model
Recruitment time
Online Access:https://doi.org/10.1186/s12874-023-02131-z

Internet

https://doi.org/10.1186/s12874-023-02131-z

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