Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study
Background and objectives: We examined sex differences in the excitatory and inhibitory functions of the primary somatosensory cortex (S1) between males and females during the early follicular phase, when estradiol hormones are unaffected. Methods: Fifty participants (25 males and 25 females) underw...
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MDPI AG
2023-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/5/761 |
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| author | Sayaka Anazawa Koya Yamashiro Taiki Makibuchi Koyuki Ikarashi Tomomi Fujimoto Genta Ochi Daisuke Sato |
| author_facet | Sayaka Anazawa Koya Yamashiro Taiki Makibuchi Koyuki Ikarashi Tomomi Fujimoto Genta Ochi Daisuke Sato |
| author_sort | Sayaka Anazawa |
| collection | DOAJ |
| description | Background and objectives: We examined sex differences in the excitatory and inhibitory functions of the primary somatosensory cortex (S1) between males and females during the early follicular phase, when estradiol hormones are unaffected. Methods: Fifty participants (25 males and 25 females) underwent measurement of somatosensory evoked potentials (SEPs) and paired-pulse inhibition (PPI) in the S1; SEPs and PPI were elicited by constant current square-wave pulses (0.2 ms duration) delivered to the right median nerve by electrical stimulation. Paired-pulse stimulation occurred at 30- and 100-ms interstimulus intervals. Participants were randomly presented with 1500 (500 stimuli each) single- and paired-pulse stimuli at 2 Hz. Results: The N20 amplitude was significantly larger in female subjects than in male subjects, and the PPI-30 ms was significantly potentiated in female subjects compared to that in male subjects. Conclusions: The excitatory and inhibitory functions in S1 differ between male and female subjects, at least during the early follicular phase. |
| first_indexed | 2024-03-11T03:53:45Z |
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| id | doaj.art-6934eaf031b741f9a2bca3ecfe8d714a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T03:53:45Z |
| publishDate | 2023-05-01 |
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| series | Brain Sciences |
| spelling | doaj.art-6934eaf031b741f9a2bca3ecfe8d714a2023-11-18T00:42:26ZengMDPI AGBrain Sciences2076-34252023-05-0113576110.3390/brainsci13050761Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary StudySayaka Anazawa0Koya Yamashiro1Taiki Makibuchi2Koyuki Ikarashi3Tomomi Fujimoto4Genta Ochi5Daisuke Sato6Field of Health and Sports, Graduate School of Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, JapanDepartment of Health and Sports, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, JapanField of Health and Sports, Graduate School of Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, JapanDepartment of Health and Sports, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, JapanDepartment of Health and Sports, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, JapanDepartment of Health and Sports, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, JapanDepartment of Health and Sports, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-Ku, Niigata 950-3198, JapanBackground and objectives: We examined sex differences in the excitatory and inhibitory functions of the primary somatosensory cortex (S1) between males and females during the early follicular phase, when estradiol hormones are unaffected. Methods: Fifty participants (25 males and 25 females) underwent measurement of somatosensory evoked potentials (SEPs) and paired-pulse inhibition (PPI) in the S1; SEPs and PPI were elicited by constant current square-wave pulses (0.2 ms duration) delivered to the right median nerve by electrical stimulation. Paired-pulse stimulation occurred at 30- and 100-ms interstimulus intervals. Participants were randomly presented with 1500 (500 stimuli each) single- and paired-pulse stimuli at 2 Hz. Results: The N20 amplitude was significantly larger in female subjects than in male subjects, and the PPI-30 ms was significantly potentiated in female subjects compared to that in male subjects. Conclusions: The excitatory and inhibitory functions in S1 differ between male and female subjects, at least during the early follicular phase.https://www.mdpi.com/2076-3425/13/5/761primary somatosensory cortex (S1)somatosensory evoked potentialspaired-pulse inhibition (PPI)sex differences |
| spellingShingle | Sayaka Anazawa Koya Yamashiro Taiki Makibuchi Koyuki Ikarashi Tomomi Fujimoto Genta Ochi Daisuke Sato Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study Brain Sciences primary somatosensory cortex (S1) somatosensory evoked potentials paired-pulse inhibition (PPI) sex differences |
| title | Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study |
| title_full | Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study |
| title_fullStr | Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study |
| title_full_unstemmed | Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study |
| title_short | Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study |
| title_sort | sex differences in excitatory and inhibitory function in the primary somatosensory cortex during the early follicular phase a preliminary study |
| topic | primary somatosensory cortex (S1) somatosensory evoked potentials paired-pulse inhibition (PPI) sex differences |
| url | https://www.mdpi.com/2076-3425/13/5/761 |
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