Investigation of Pathergy In Patients With Fibromyalgia
Aim: Recent studies showed increased axon reflex flare reaction to mechanical and chemical stimuli associated with neurogenic inflammation in patients with fibromyalgia (FM). Pathergy test is identified as a non-specific hypersensitivity reaction to minimal trauma. The purpose of this study was to i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mustafa Kemal University
2015-03-01
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| Series: | Mustafa Kemal Üniversitesi Tıp Dergisi |
| Subjects: | |
| Online Access: | http://dergipark.gov.tr/mkutfd/issue/19600/209469?publisher=mku |
| _version_ | 1797918626395717632 |
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| author | Pelin Oktayoğlu Mehtap Bozkurt Mehmet Çağlayan Sabahattin Verim Kemal Nas |
| author_facet | Pelin Oktayoğlu Mehtap Bozkurt Mehmet Çağlayan Sabahattin Verim Kemal Nas |
| author_sort | Pelin Oktayoğlu |
| collection | DOAJ |
| description | Aim: Recent studies showed increased axon reflex flare reaction to mechanical and chemical stimuli associated with neurogenic inflammation in patients with fibromyalgia (FM). Pathergy test is identified as a non-specific hypersensitivity reaction to minimal trauma. The purpose of this study was to investigate whether patients with FM had a positive pathergy test or not.Methods: Forty-six patients who met the 1990 American College of Rheumatology (ACR) criteria for the classification of FM and fifty-one healthy control subjects (HCs) were included in this study. Twenty-eight patients with Behcet’s disease were included as disease control for Pathergy test. The Fibromyalgia Impact Questionnaire (FIQ) was used for assessment of functional status in patients with FM. The Nottingham Health Profile was used for assessment of quality of life in all subjects.Results: There was no significant difference in demographic characteristics between the three groups (p > 0.05). NHP-pain, NHP-physical mobility, NHP-energy, NHP-emotional reaction, NHP-sleep and NHP-total scores were significantly higher in patients with FM compared to HCs (p < 0.001). Neither patients with FM nor HCs had a positive pathergy test.Conclusion: There are some pathophysiological changes in the skin biopsies of patients with FM; however, these changes are not accompanied by a positive pathergy test.Key Words: Fibromyalgia, Pathergy test |
| first_indexed | 2024-04-10T13:32:15Z |
| format | Article |
| id | doaj.art-693551063b3d4f71a5a430c74bad231f |
| institution | Directory Open Access Journal |
| issn | 2149-3103 |
| language | English |
| last_indexed | 2024-04-10T13:32:15Z |
| publishDate | 2015-03-01 |
| publisher | Mustafa Kemal University |
| record_format | Article |
| series | Mustafa Kemal Üniversitesi Tıp Dergisi |
| spelling | doaj.art-693551063b3d4f71a5a430c74bad231f2023-02-15T16:11:32ZengMustafa Kemal UniversityMustafa Kemal Üniversitesi Tıp Dergisi2149-31032015-03-0162110.17944/mkutfd.32623102Investigation of Pathergy In Patients With FibromyalgiaPelin OktayoğluMehtap BozkurtMehmet ÇağlayanSabahattin VerimKemal NasAim: Recent studies showed increased axon reflex flare reaction to mechanical and chemical stimuli associated with neurogenic inflammation in patients with fibromyalgia (FM). Pathergy test is identified as a non-specific hypersensitivity reaction to minimal trauma. The purpose of this study was to investigate whether patients with FM had a positive pathergy test or not.Methods: Forty-six patients who met the 1990 American College of Rheumatology (ACR) criteria for the classification of FM and fifty-one healthy control subjects (HCs) were included in this study. Twenty-eight patients with Behcet’s disease were included as disease control for Pathergy test. The Fibromyalgia Impact Questionnaire (FIQ) was used for assessment of functional status in patients with FM. The Nottingham Health Profile was used for assessment of quality of life in all subjects.Results: There was no significant difference in demographic characteristics between the three groups (p > 0.05). NHP-pain, NHP-physical mobility, NHP-energy, NHP-emotional reaction, NHP-sleep and NHP-total scores were significantly higher in patients with FM compared to HCs (p < 0.001). Neither patients with FM nor HCs had a positive pathergy test.Conclusion: There are some pathophysiological changes in the skin biopsies of patients with FM; however, these changes are not accompanied by a positive pathergy test.Key Words: Fibromyalgia, Pathergy testhttp://dergipark.gov.tr/mkutfd/issue/19600/209469?publisher=mku--Fibromiyalji Paterji |
| spellingShingle | Pelin Oktayoğlu Mehtap Bozkurt Mehmet Çağlayan Sabahattin Verim Kemal Nas Investigation of Pathergy In Patients With Fibromyalgia Mustafa Kemal Üniversitesi Tıp Dergisi - - Fibromiyalji Paterji |
| title | Investigation of Pathergy In Patients With Fibromyalgia |
| title_full | Investigation of Pathergy In Patients With Fibromyalgia |
| title_fullStr | Investigation of Pathergy In Patients With Fibromyalgia |
| title_full_unstemmed | Investigation of Pathergy In Patients With Fibromyalgia |
| title_short | Investigation of Pathergy In Patients With Fibromyalgia |
| title_sort | investigation of pathergy in patients with fibromyalgia |
| topic | - - Fibromiyalji Paterji |
| url | http://dergipark.gov.tr/mkutfd/issue/19600/209469?publisher=mku |
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