Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States
Abstract Background Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using a novel or hydrolysate protein‐based food. Objective To evaluate a therapeutic food containing egg and phytonutrients in dogs with food allergies using an activity mo...
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.16193 |
| _version_ | 1818588841396666368 |
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| author | James L. Weemhoff Jennifer M. MacLeay John Brejda Heidi Schiefelbein Susan M. Wernimont Kathy L. Gross |
| author_facet | James L. Weemhoff Jennifer M. MacLeay John Brejda Heidi Schiefelbein Susan M. Wernimont Kathy L. Gross |
| author_sort | James L. Weemhoff |
| collection | DOAJ |
| description | Abstract Background Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using a novel or hydrolysate protein‐based food. Objective To evaluate a therapeutic food containing egg and phytonutrients in dogs with food allergies using an activity monitor and core outcome set for canine atopic dermatitis (COSCAD'18) guidelines and in a controlled double‐masked, multicenter, prospective clinical trial. Animals Adult dogs with a history of adverse food reaction as diagnosed by a food elimination trial were recruited from general practices. Methods After a 21‐day baseline period, dogs were randomized to test or positive control (hydrolyzed protein) food for 21 days. Owner (pruritus visual analog score [PVAS], coat quality, food acceptance, and satisfaction) and veterinarian (canine atopic dermatitis lesion index [CADLI], physical examination) assessments were completed on days 0, 21, and 42. Dogs wore a collar‐mounted activity monitor to record scratching and shaking behavior throughout the study. Statistical analysis included within‐group comparison to baseline and between‐group comparison at study end using a significance threshold of alpha = 0.05. Results At the end of the treatment period, all results were similar between groups for CADLI, PVAS, owner satisfaction, activity, and questionnaire data. Scores for hair dullness, brittleness, amount of dandruff, feces quality, and food acceptance were positive and not statistically different between groups. Conclusions and Clinical Importance The therapeutic test food was well‐accepted and efficacious in managing signs of adverse reactions to food compared to baseline as well as compared to the positive control food. |
| first_indexed | 2024-12-16T09:31:10Z |
| format | Article |
| id | doaj.art-693552b3380244f2b731b927aaa4815e |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-16T09:31:10Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-693552b3380244f2b731b927aaa4815e2022-12-21T22:36:32ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-07-013541884189210.1111/jvim.16193Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United StatesJames L. Weemhoff0Jennifer M. MacLeay1John Brejda2Heidi Schiefelbein3Susan M. Wernimont4Kathy L. Gross5Pet Nutrition Center Hill's Pet Nutrition, Inc Topeka, Kansas 66616 USAPet Nutrition Center Hill's Pet Nutrition, Inc Topeka, Kansas 66616 USAAlpha Statistics Lincoln Nebraska USAPet Nutrition Center Hill's Pet Nutrition, Inc Topeka, Kansas 66616 USAPet Nutrition Center Hill's Pet Nutrition, Inc Topeka, Kansas 66616 USAPet Nutrition Center Hill's Pet Nutrition, Inc Topeka, Kansas 66616 USAAbstract Background Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using a novel or hydrolysate protein‐based food. Objective To evaluate a therapeutic food containing egg and phytonutrients in dogs with food allergies using an activity monitor and core outcome set for canine atopic dermatitis (COSCAD'18) guidelines and in a controlled double‐masked, multicenter, prospective clinical trial. Animals Adult dogs with a history of adverse food reaction as diagnosed by a food elimination trial were recruited from general practices. Methods After a 21‐day baseline period, dogs were randomized to test or positive control (hydrolyzed protein) food for 21 days. Owner (pruritus visual analog score [PVAS], coat quality, food acceptance, and satisfaction) and veterinarian (canine atopic dermatitis lesion index [CADLI], physical examination) assessments were completed on days 0, 21, and 42. Dogs wore a collar‐mounted activity monitor to record scratching and shaking behavior throughout the study. Statistical analysis included within‐group comparison to baseline and between‐group comparison at study end using a significance threshold of alpha = 0.05. Results At the end of the treatment period, all results were similar between groups for CADLI, PVAS, owner satisfaction, activity, and questionnaire data. Scores for hair dullness, brittleness, amount of dandruff, feces quality, and food acceptance were positive and not statistically different between groups. Conclusions and Clinical Importance The therapeutic test food was well‐accepted and efficacious in managing signs of adverse reactions to food compared to baseline as well as compared to the positive control food.https://doi.org/10.1111/jvim.16193activity monitorcanine adverse food reactionseggnovel proteinpruritus |
| spellingShingle | James L. Weemhoff Jennifer M. MacLeay John Brejda Heidi Schiefelbein Susan M. Wernimont Kathy L. Gross Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States Journal of Veterinary Internal Medicine activity monitor canine adverse food reactions egg novel protein pruritus |
| title | Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States |
| title_full | Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States |
| title_fullStr | Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States |
| title_full_unstemmed | Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States |
| title_short | Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD'18 adherent clinical trial in dogs in the United States |
| title_sort | successful nutritional control of scratching and clinical signs associated with adverse food reaction a randomized controlled coscad 18 adherent clinical trial in dogs in the united states |
| topic | activity monitor canine adverse food reactions egg novel protein pruritus |
| url | https://doi.org/10.1111/jvim.16193 |
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