Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China
Abstract Background It is generally acknowledged that the determination of harmful chemical compounds excreted into saliva is useful for assessing their exposure levels. The aim of the present study was to compare the total arsenic and its species in saliva and urine samples collected from the peopl...
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Komiyama Printing Co. Ltd
2017-05-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12199-017-0652-5 |
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| author | Dapeng Wang Yasuyo Shimoda Sanxiang Wang Zhenghui Wang Jian Liu Xing Liu Huanyu Jin Fenfang Gao Jian Tong Kenzo Yamanaka Jie Zhang Yan An |
| author_facet | Dapeng Wang Yasuyo Shimoda Sanxiang Wang Zhenghui Wang Jian Liu Xing Liu Huanyu Jin Fenfang Gao Jian Tong Kenzo Yamanaka Jie Zhang Yan An |
| author_sort | Dapeng Wang |
| collection | DOAJ |
| description | Abstract Background It is generally acknowledged that the determination of harmful chemical compounds excreted into saliva is useful for assessing their exposure levels. The aim of the present study was to compare the total arsenic and its species in saliva and urine samples collected from the people residing in an arsenic-contaminated area of China and to further verify the feasibility of using salivary arsenic as a new biomarker of arsenic exposure. Methods Total arsenic and speciation analyses in urine and saliva samples among 70 residents exposed to arsenic from drinking water in Shanxi, China were carried out by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP/MS). Results The result showed that, total arsenic concentration in saliva was relatively lower than in urine samples, but it existed a strong positive correlation with total urinary arsenic, drinking water arsenic and different skin lesions. For arsenic metabolism analyses, AsIII, AsV, MMA, and DMA were detected in all of the urine samples with the dominating species of DMA (73.2%). Different with urinary arsenic species, most arsenic species in saliva were not methylated. The major species in saliva was iAs (AsIII + AsV, 76.18%), followed by DMA (13.08%) and MMA (9.13%). And the primary methylation index (PMI), second methylation index (SMI) and proportion of the four different species (AsIII, AsV, MMA, and DMA) in saliva showed no significant positive relationship with that of in urine. Conclusions These findings indicated saliva may be used as a useful tool for biological monitoring of total arsenic exposure in the crowd rather than an efficient tool for assessing arsenic metabolism in human body after exposed to arsenic. |
| first_indexed | 2024-12-10T22:05:01Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-12-10T22:05:01Z |
| publishDate | 2017-05-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-6937e16c5fad437fb34bf01536ee5f342022-12-22T01:31:47ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152017-05-012211910.1186/s12199-017-0652-5Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in ChinaDapeng Wang0Yasuyo Shimoda1Sanxiang Wang2Zhenghui Wang3Jian Liu4Xing Liu5Huanyu Jin6Fenfang Gao7Jian Tong8Kenzo Yamanaka9Jie Zhang10Yan An11Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityLaboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon UniversityShanxi Institute for Prevention and Treatment of Endemic DiseaseShanxi Institute for Prevention and Treatment of Endemic DiseaseDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityLaboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon UniversityDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow UniversityAbstract Background It is generally acknowledged that the determination of harmful chemical compounds excreted into saliva is useful for assessing their exposure levels. The aim of the present study was to compare the total arsenic and its species in saliva and urine samples collected from the people residing in an arsenic-contaminated area of China and to further verify the feasibility of using salivary arsenic as a new biomarker of arsenic exposure. Methods Total arsenic and speciation analyses in urine and saliva samples among 70 residents exposed to arsenic from drinking water in Shanxi, China were carried out by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP/MS). Results The result showed that, total arsenic concentration in saliva was relatively lower than in urine samples, but it existed a strong positive correlation with total urinary arsenic, drinking water arsenic and different skin lesions. For arsenic metabolism analyses, AsIII, AsV, MMA, and DMA were detected in all of the urine samples with the dominating species of DMA (73.2%). Different with urinary arsenic species, most arsenic species in saliva were not methylated. The major species in saliva was iAs (AsIII + AsV, 76.18%), followed by DMA (13.08%) and MMA (9.13%). And the primary methylation index (PMI), second methylation index (SMI) and proportion of the four different species (AsIII, AsV, MMA, and DMA) in saliva showed no significant positive relationship with that of in urine. Conclusions These findings indicated saliva may be used as a useful tool for biological monitoring of total arsenic exposure in the crowd rather than an efficient tool for assessing arsenic metabolism in human body after exposed to arsenic.http://link.springer.com/article/10.1186/s12199-017-0652-5Arsenic speciationSalivaUrineDrinking waterBiomarker |
| spellingShingle | Dapeng Wang Yasuyo Shimoda Sanxiang Wang Zhenghui Wang Jian Liu Xing Liu Huanyu Jin Fenfang Gao Jian Tong Kenzo Yamanaka Jie Zhang Yan An Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China Environmental Health and Preventive Medicine Arsenic speciation Saliva Urine Drinking water Biomarker |
| title | Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China |
| title_full | Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China |
| title_fullStr | Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China |
| title_full_unstemmed | Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China |
| title_short | Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China |
| title_sort | total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in china |
| topic | Arsenic speciation Saliva Urine Drinking water Biomarker |
| url | http://link.springer.com/article/10.1186/s12199-017-0652-5 |
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