Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis
The parameters of acute toxicity of azomethine "C-18" and blood indicatorsin young cattle, naturally invaded by nematodiruses before and after treatment with this remedyand various anti-helmintic drugs, were studied. The therapeutic dose of azomethine in calvesaffected with nematodirosis w...
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| Format: | Article |
| Language: | Russian |
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Federal Agricultural Research Center of the North-East named N.V. Rudnitsky
2021-02-01
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| Series: | Аграрная наука Евро-Северо-Востока |
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| Online Access: | https://www.agronauka-sv.ru/jour/article/view/687 |
| _version_ | 1797290271077040128 |
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| author | R. I. Shangaraev M. H. Lutfullin R. R. Timerbayeva R. R. Guizzatullin R. R. Gizzatullina |
| author_facet | R. I. Shangaraev M. H. Lutfullin R. R. Timerbayeva R. R. Guizzatullin R. R. Gizzatullina |
| author_sort | R. I. Shangaraev |
| collection | DOAJ |
| description | The parameters of acute toxicity of azomethine "C-18" and blood indicatorsin young cattle, naturally invaded by nematodiruses before and after treatment with this remedyand various anti-helmintic drugs, were studied. The therapeutic dose of azomethine in calvesaffected with nematodirosis was titrated. In the first experiment, the acute toxicity of azomethine "С-18" was studied in white outbred mice and rats. As the result of the studies, the average death dose of azomethine "С-18" was not established. The maximum dose administered was 2000 mg/kg. There was nolossin laboratory animals. In the second experiment, the effect of azomethine "С-18" on the blood indicators of helminth-infested cattle was investigated. It was established that in the blood of calves naturally infected with nematodiruses there were: erythropenia, hypohemoglobinemia, leukocytosis, eosinophilia, lymphocytopenia, giproteinemia, hypoglycemia, increased transaminase activity. After deworming these animals withtetramizole granulate, 10% albendazole suspension and azomethine "С-18" broken hematological parameters were completely restored up to physiological norm on the 30-th day. In the third experiment, the effect of different doses of azomethine "С-18" on the hematological indices of healthy cattle were studied. The animals were orally administered azomethine "С-18" in doses of 50.0 and 100.0 mg/kg. After that hypoglycemia, increased alkaline phosphatase activity and reduced urea content were found in serum ofcalves. In the fourth experiment, the anthelmintic efficacy of various doses of azomethine "С-18" in cattle affected with nematodirosiswas studied. It has been established that azomethine "С-18" in doses 2; 5; 10; 15 and 20 mg/kg showed approximately the sameintensity of efficacy, which ranged from 95.3 to 97.9%. The extensity of efficacywas 87.5%. The therapeutic dose was 2.0 mg/kg. |
| first_indexed | 2024-03-07T19:20:02Z |
| format | Article |
| id | doaj.art-6939524822cb4c478f4def2da9e6e127 |
| institution | Directory Open Access Journal |
| issn | 2072-9081 2500-1396 |
| language | Russian |
| last_indexed | 2024-03-07T19:20:02Z |
| publishDate | 2021-02-01 |
| publisher | Federal Agricultural Research Center of the North-East named N.V. Rudnitsky |
| record_format | Article |
| series | Аграрная наука Евро-Северо-Востока |
| spelling | doaj.art-6939524822cb4c478f4def2da9e6e1272024-02-29T11:31:12ZrusFederal Agricultural Research Center of the North-East named N.V. RudnitskyАграрная наука Евро-Северо-Востока2072-90812500-13962021-02-0122110411810.30766/2072-9081.2021.22.1.104-118454Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosisR. I. Shangaraev0M. H. Lutfullin1R. R. Timerbayeva2R. R. Guizzatullin3R. R. Gizzatullina4Kazan State Academy of Veterinary Medicine named after N. E. BaumanKazan State Academy of Veterinary Medicine named after N. E. BaumanKazan State Academy of Veterinary Medicine named after N. E. BaumanKazan State Academy of Veterinary Medicine named after N. E. BaumanKazan State Academy of Veterinary Medicine named after N. E. BaumanThe parameters of acute toxicity of azomethine "C-18" and blood indicatorsin young cattle, naturally invaded by nematodiruses before and after treatment with this remedyand various anti-helmintic drugs, were studied. The therapeutic dose of azomethine in calvesaffected with nematodirosis was titrated. In the first experiment, the acute toxicity of azomethine "С-18" was studied in white outbred mice and rats. As the result of the studies, the average death dose of azomethine "С-18" was not established. The maximum dose administered was 2000 mg/kg. There was nolossin laboratory animals. In the second experiment, the effect of azomethine "С-18" on the blood indicators of helminth-infested cattle was investigated. It was established that in the blood of calves naturally infected with nematodiruses there were: erythropenia, hypohemoglobinemia, leukocytosis, eosinophilia, lymphocytopenia, giproteinemia, hypoglycemia, increased transaminase activity. After deworming these animals withtetramizole granulate, 10% albendazole suspension and azomethine "С-18" broken hematological parameters were completely restored up to physiological norm on the 30-th day. In the third experiment, the effect of different doses of azomethine "С-18" on the hematological indices of healthy cattle were studied. The animals were orally administered azomethine "С-18" in doses of 50.0 and 100.0 mg/kg. After that hypoglycemia, increased alkaline phosphatase activity and reduced urea content were found in serum ofcalves. In the fourth experiment, the anthelmintic efficacy of various doses of azomethine "С-18" in cattle affected with nematodirosiswas studied. It has been established that azomethine "С-18" in doses 2; 5; 10; 15 and 20 mg/kg showed approximately the sameintensity of efficacy, which ranged from 95.3 to 97.9%. The extensity of efficacywas 87.5%. The therapeutic dose was 2.0 mg/kg.https://www.agronauka-sv.ru/jour/article/view/687anthelminthic drugsbiochemical indicatorsintensity of efficacybloodmorphological indicatorsacute toxicityextensity of efficacy |
| spellingShingle | R. I. Shangaraev M. H. Lutfullin R. R. Timerbayeva R. R. Guizzatullin R. R. Gizzatullina Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis Аграрная наука Евро-Северо-Востока anthelminthic drugs biochemical indicators intensity of efficacy blood morphological indicators acute toxicity extensity of efficacy |
| title | Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis |
| title_full | Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis |
| title_fullStr | Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis |
| title_full_unstemmed | Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis |
| title_short | Toxicological assessment of azomethine «C-18» and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis |
| title_sort | toxicological assessment of azomethine c 18 and study of anthelmintic efficacy of its various doses in cattle affected with nematodirosis |
| topic | anthelminthic drugs biochemical indicators intensity of efficacy blood morphological indicators acute toxicity extensity of efficacy |
| url | https://www.agronauka-sv.ru/jour/article/view/687 |
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