Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid
Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/4/83 |
| _version_ | 1797537385192357888 |
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| author | Navid Kashaninejad Ahmed Munaz Hajar Moghadas Sharda Yadav Muhammad Umer Nam-Trung Nguyen |
| author_facet | Navid Kashaninejad Ahmed Munaz Hajar Moghadas Sharda Yadav Muhammad Umer Nam-Trung Nguyen |
| author_sort | Navid Kashaninejad |
| collection | DOAJ |
| description | Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs, and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection are discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays is discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed. |
| first_indexed | 2024-03-10T12:14:25Z |
| format | Article |
| id | doaj.art-693a073db6134dc68455ebf34278b1ed |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T12:14:25Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-693a073db6134dc68455ebf34278b1ed2023-11-21T15:56:23ZengMDPI AGChemosensors2227-90402021-04-01948310.3390/chemosensors9040083Microneedle Arrays for Sampling and Sensing Skin Interstitial FluidNavid Kashaninejad0Ahmed Munaz1Hajar Moghadas2Sharda Yadav3Muhammad Umer4Nam-Trung Nguyen5Queensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane QLD 4111, AustraliaQueensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane QLD 4111, AustraliaDepartment of Mechanical Engineering, Gas and Petroleum Faculty, Yasouj University, Yasuj 75918-74831, IranQueensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane QLD 4111, AustraliaQueensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane QLD 4111, AustraliaQueensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane QLD 4111, AustraliaDermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs, and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection are discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays is discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed.https://www.mdpi.com/2227-9040/9/4/83microneedlemicroneedle arrayinterstitial fluidbio sensingwearable systemISF sampling |
| spellingShingle | Navid Kashaninejad Ahmed Munaz Hajar Moghadas Sharda Yadav Muhammad Umer Nam-Trung Nguyen Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid Chemosensors microneedle microneedle array interstitial fluid bio sensing wearable system ISF sampling |
| title | Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid |
| title_full | Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid |
| title_fullStr | Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid |
| title_full_unstemmed | Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid |
| title_short | Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid |
| title_sort | microneedle arrays for sampling and sensing skin interstitial fluid |
| topic | microneedle microneedle array interstitial fluid bio sensing wearable system ISF sampling |
| url | https://www.mdpi.com/2227-9040/9/4/83 |
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