Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats
Purpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2016-07-01
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| Series: | Sleep Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1984006316300827 |
| _version_ | 1797369941670756352 |
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| author | Fabio Santos Lira Andrea Maculano Esteves Gustavo Duarte Pimentel José Cesar Rosa Miriam Kannebley Frank Melise Oliveira Mariano Josiane Budni João Quevedo Ronaldo Vagner dos Santos Marco Túlio de Mello |
| author_facet | Fabio Santos Lira Andrea Maculano Esteves Gustavo Duarte Pimentel José Cesar Rosa Miriam Kannebley Frank Melise Oliveira Mariano Josiane Budni João Quevedo Ronaldo Vagner dos Santos Marco Túlio de Mello |
| author_sort | Fabio Santos Lira |
| collection | DOAJ |
| description | Purpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group.
Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test.
Results: In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p<0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p<0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p<0.05).
Conclusions: Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity. |
| first_indexed | 2024-03-08T17:54:15Z |
| format | Article |
| id | doaj.art-693afa95e4a94829af5d787aa5627251 |
| institution | Directory Open Access Journal |
| issn | 1984-0063 |
| language | English |
| last_indexed | 2024-03-08T17:54:15Z |
| publishDate | 2016-07-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Sleep Science |
| spelling | doaj.art-693afa95e4a94829af5d787aa56272512024-01-02T05:42:57ZengThieme Revinter Publicações Ltda.Sleep Science1984-00632016-07-019323223510.1016/j.slsci.2016.10.006Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing ratsFabio Santos Lira0Andrea Maculano Esteves1Gustavo Duarte Pimentel2José Cesar Rosa3Miriam Kannebley Frank4Melise Oliveira Mariano5Josiane Budni6João Quevedo7Ronaldo Vagner dos Santos8Marco Túlio de Mello9Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, SP, BrazilFaculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, BrazilLaboratory of Research in Clinical Nutrition and Sports (Labince), Nutrition Faculty (FANUT), Federal University of Goias (UFG), Goiânia, GO, BrazilInstituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, BrazilFaculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, BrazilDepartamento de Psicobiologia, Universidade Federal de São Paulo, BrazilLaboratory of Neurosciences, National Institute for Translational Medicine, and Center of Excellence in Applied Neurosciences of Santa Catarina, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, BrazilLaboratory of Neurosciences, National Institute for Translational Medicine, and Center of Excellence in Applied Neurosciences of Santa Catarina, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, BrazilDepartamento de Biociências, Universidade Federal de São Paulo, Santos, BrazilDepartamento de Esportes, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilPurpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test. Results: In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p<0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p<0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p<0.05). Conclusions: Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity.http://www.sciencedirect.com/science/article/pii/S1984006316300827SleepLocomotor activityDoxorubicinRats |
| spellingShingle | Fabio Santos Lira Andrea Maculano Esteves Gustavo Duarte Pimentel José Cesar Rosa Miriam Kannebley Frank Melise Oliveira Mariano Josiane Budni João Quevedo Ronaldo Vagner dos Santos Marco Túlio de Mello Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats Sleep Science Sleep Locomotor activity Doxorubicin Rats |
| title | Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
| title_full | Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
| title_fullStr | Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
| title_full_unstemmed | Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
| title_short | Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats |
| title_sort | sleep pattern and locomotor activity are impaired by doxorubicin in non tumor bearing rats |
| topic | Sleep Locomotor activity Doxorubicin Rats |
| url | http://www.sciencedirect.com/science/article/pii/S1984006316300827 |
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