Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine
Harmaline-induced tremor is one of the most commonly utilized disease models for essential tremor (ET). However, the underlying neural networks involved in harmaline-induced tremor and the degree to which these are a representative model of the pathophysiologic mechanism of ET are incompletely under...
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| Format: | Article |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00985/full |
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| author | Jeyeon Lee Hang Joon Jo Hang Joon Jo Hang Joon Jo Hang Joon Jo Inyong Kim Jihyun Lee Hoon-Ki Min Myung-Ho In Emily J. Knight Su-Youne Chang Su-Youne Chang |
| author_facet | Jeyeon Lee Hang Joon Jo Hang Joon Jo Hang Joon Jo Hang Joon Jo Inyong Kim Jihyun Lee Hoon-Ki Min Myung-Ho In Emily J. Knight Su-Youne Chang Su-Youne Chang |
| author_sort | Jeyeon Lee |
| collection | DOAJ |
| description | Harmaline-induced tremor is one of the most commonly utilized disease models for essential tremor (ET). However, the underlying neural networks involved in harmaline-induced tremor and the degree to which these are a representative model of the pathophysiologic mechanism of ET are incompletely understood. In this study, we evaluated the functional brain network effects induced by systemic injection of harmaline using pharmacological functional magnetic resonance imaging (ph-fMRI) in the swine model. With harmaline administration, we observed significant activation changes in cerebellum, thalamus, and inferior olivary nucleus (ION). In addition, inter-regional correlations in activity between cerebellum and deep cerebellar nuclei and between cerebellum and thalamus were significantly enhanced. These harmaline-induced effects gradually decreased with repeated administration of drug, replicating the previously demonstrated ‘tolerance’ effect. This study demonstrates that harmaline-induced tremor is associated with activity changes in brain regions previously implicated in humans with ET. Thus, harmaline-induction of tremor in the swine may be a useful model to explore the neurological effects of novel therapeutic agents and/or neuromodulation techniques for ET. |
| first_indexed | 2024-12-22T08:18:31Z |
| format | Article |
| id | doaj.art-693b44cacb734f4ea25358121acf56e9 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T08:18:31Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-693b44cacb734f4ea25358121acf56e92022-12-21T18:32:49ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-09-011310.3389/fnins.2019.00985459486Mapping BOLD Activation by Pharmacologically Evoked Tremor in SwineJeyeon Lee0Hang Joon Jo1Hang Joon Jo2Hang Joon Jo3Hang Joon Jo4Inyong Kim5Jihyun Lee6Hoon-Ki Min7Myung-Ho In8Emily J. Knight9Su-Youne Chang10Su-Youne Chang11Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United StatesDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiology, Mayo Clinic, Rochester, MN, United StatesDepartment of Neurology, Mayo Clinic, Rochester, MN, United StatesDepartment of Physiology, College of Medicine, Hanyang University, Seoul, South KoreaDepartment of Neurology, Mayo Clinic, Rochester, MN, United StatesLaboratory of Brain and Cognitive Sciences for Convergence Medicine, Hallym University College of Medicine, Anyang, South KoreaDepartment of Radiology, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiology, Mayo Clinic, Rochester, MN, United StatesDepartment of Developmental Behavioral Pediatrics, University of Rochester, Rochester, NY, United StatesDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, United StatesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United StatesHarmaline-induced tremor is one of the most commonly utilized disease models for essential tremor (ET). However, the underlying neural networks involved in harmaline-induced tremor and the degree to which these are a representative model of the pathophysiologic mechanism of ET are incompletely understood. In this study, we evaluated the functional brain network effects induced by systemic injection of harmaline using pharmacological functional magnetic resonance imaging (ph-fMRI) in the swine model. With harmaline administration, we observed significant activation changes in cerebellum, thalamus, and inferior olivary nucleus (ION). In addition, inter-regional correlations in activity between cerebellum and deep cerebellar nuclei and between cerebellum and thalamus were significantly enhanced. These harmaline-induced effects gradually decreased with repeated administration of drug, replicating the previously demonstrated ‘tolerance’ effect. This study demonstrates that harmaline-induced tremor is associated with activity changes in brain regions previously implicated in humans with ET. Thus, harmaline-induction of tremor in the swine may be a useful model to explore the neurological effects of novel therapeutic agents and/or neuromodulation techniques for ET.https://www.frontiersin.org/article/10.3389/fnins.2019.00985/fulltremoressential tremorharmaline-induced tremorpharmacological fMRIswine modelpig |
| spellingShingle | Jeyeon Lee Hang Joon Jo Hang Joon Jo Hang Joon Jo Hang Joon Jo Inyong Kim Jihyun Lee Hoon-Ki Min Myung-Ho In Emily J. Knight Su-Youne Chang Su-Youne Chang Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine Frontiers in Neuroscience tremor essential tremor harmaline-induced tremor pharmacological fMRI swine model pig |
| title | Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine |
| title_full | Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine |
| title_fullStr | Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine |
| title_full_unstemmed | Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine |
| title_short | Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine |
| title_sort | mapping bold activation by pharmacologically evoked tremor in swine |
| topic | tremor essential tremor harmaline-induced tremor pharmacological fMRI swine model pig |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00985/full |
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