Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart
(1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, scheduled to be sacrificed after the second, third, and fo...
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MDPI AG
2022-08-01
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| author | Jasmina Sretenovic Vladimir Zivkovic Ivan Srejovic Suzana Pantovic Jovana Joksimovic Jovic Maja Nikolic Tamara Nikolic Turnic Maja Savic Maja Jevdjevic Zoran Milosavljevic Sergej Bolevich Vladimir Jakovljevic |
| author_facet | Jasmina Sretenovic Vladimir Zivkovic Ivan Srejovic Suzana Pantovic Jovana Joksimovic Jovic Maja Nikolic Tamara Nikolic Turnic Maja Savic Maja Jevdjevic Zoran Milosavljevic Sergej Bolevich Vladimir Jakovljevic |
| author_sort | Jasmina Sretenovic |
| collection | DOAJ |
| description | (1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, scheduled to be sacrificed after the second, third, and fourth week. Each group was divided into four subgroups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training plus nandrolone (T+N+) group. The rats from T+N- and T+N+ swam 1 h/day, 5 days/week while ones from T-N+ and T+N+ received weekly nandrolone decanoate (20 mg/kg). The isolated hearts were perfused according to the Langendorff technique and measured parameters: dp/dt max/min, SLVP, DLVP, heart rate, and coronary flow. Hearts were fixed and stained with H/E and Masson trichrome dyes. (3) dp/dt max and dp/dt min were increased in the T-N+ group at higher perfusion pressure compared to the T-N- group. SLVP and DLVP were increased in all groups after the 4th week. Collagen content was increased in T-N+ by 403% and in T+N+ by 357% groups, while it was decreased in T+N- compared to the control after 4th week. (4) Conclusions: Nandrolone alone or combined with swimming had a deleterious effect on myocardial function and perfusion. |
| first_indexed | 2024-03-09T04:11:41Z |
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| language | English |
| last_indexed | 2024-03-09T04:11:41Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-693b66d67a034b76936cc779121b4c672023-12-03T13:59:00ZengMDPI AGLife2075-17292022-08-01128124210.3390/life12081242Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat HeartJasmina Sretenovic0Vladimir Zivkovic1Ivan Srejovic2Suzana Pantovic3Jovana Joksimovic Jovic4Maja Nikolic5Tamara Nikolic Turnic6Maja Savic7Maja Jevdjevic8Zoran Milosavljevic9Sergej Bolevich10Vladimir Jakovljevic11Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Human Pathology, 1st Moscow State Medical University IM Sechenov, Trubetskaya Str. 2, 119992 Moscow, RussiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia(1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, scheduled to be sacrificed after the second, third, and fourth week. Each group was divided into four subgroups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training plus nandrolone (T+N+) group. The rats from T+N- and T+N+ swam 1 h/day, 5 days/week while ones from T-N+ and T+N+ received weekly nandrolone decanoate (20 mg/kg). The isolated hearts were perfused according to the Langendorff technique and measured parameters: dp/dt max/min, SLVP, DLVP, heart rate, and coronary flow. Hearts were fixed and stained with H/E and Masson trichrome dyes. (3) dp/dt max and dp/dt min were increased in the T-N+ group at higher perfusion pressure compared to the T-N- group. SLVP and DLVP were increased in all groups after the 4th week. Collagen content was increased in T-N+ by 403% and in T+N+ by 357% groups, while it was decreased in T+N- compared to the control after 4th week. (4) Conclusions: Nandrolone alone or combined with swimming had a deleterious effect on myocardial function and perfusion.https://www.mdpi.com/2075-1729/12/8/1242isolated rat heartcardiodynamicsnandrolone decanoatemorphometrycollagen |
| spellingShingle | Jasmina Sretenovic Vladimir Zivkovic Ivan Srejovic Suzana Pantovic Jovana Joksimovic Jovic Maja Nikolic Tamara Nikolic Turnic Maja Savic Maja Jevdjevic Zoran Milosavljevic Sergej Bolevich Vladimir Jakovljevic Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart Life isolated rat heart cardiodynamics nandrolone decanoate morphometry collagen |
| title | Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart |
| title_full | Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart |
| title_fullStr | Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart |
| title_full_unstemmed | Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart |
| title_short | Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart |
| title_sort | nandrolone decanoate and swimming affects cardiodynamic and morphometric parameters in the isolated rat heart |
| topic | isolated rat heart cardiodynamics nandrolone decanoate morphometry collagen |
| url | https://www.mdpi.com/2075-1729/12/8/1242 |
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