Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway
Autoimmune disease: Bach2 orchestrates immune function Bach2, a protein that regulates gene expression, is required in the B cells and T cells of the immune system to protect against autoimmune disease. Bach2 deficiency has previously been associated with systemic lupus erythematosus (SLE), but the...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-12-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0352-x |
| _version_ | 1818594687602130944 |
|---|---|
| author | Eunkyeong Jang Un Kyo Kim Kiseok Jang Young Soo Song Ji-Young Cha Hansol Yi Jeehee Youn |
| author_facet | Eunkyeong Jang Un Kyo Kim Kiseok Jang Young Soo Song Ji-Young Cha Hansol Yi Jeehee Youn |
| author_sort | Eunkyeong Jang |
| collection | DOAJ |
| description | Autoimmune disease: Bach2 orchestrates immune function Bach2, a protein that regulates gene expression, is required in the B cells and T cells of the immune system to protect against autoimmune disease. Bach2 deficiency has previously been associated with systemic lupus erythematosus (SLE), but the mechanisms through which it contributes to the development of an immune response against healthy tissue in many parts of the body were unclear. Jeehee Youn at Hanyang University in Seoul, South Korea, and colleagues showed that B cells from mice lacking Bach2 produce self-reactive antibodies and express SLE-related genes. Furthermore, when they specifically deleted Bach2 in T cells, they found that it triggered differentiation into a type of T cell which promoted the maturation of self-reactive B cells. The authors conclude that Bach2 activity in both B cells and T cells is key to maintaining immune self-tolerance. |
| first_indexed | 2024-12-16T11:04:05Z |
| format | Article |
| id | doaj.art-693c5dc5fb704e97bbdeb8bbe5dbb7c6 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-16T11:04:05Z |
| publishDate | 2019-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-693c5dc5fb704e97bbdeb8bbe5dbb7c62022-12-21T22:33:55ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-12-01511211310.1038/s12276-019-0352-xBach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathwayEunkyeong Jang0Un Kyo Kim1Kiseok Jang2Young Soo Song3Ji-Young Cha4Hansol Yi5Jeehee Youn6Laboratory of Autoimmunology, Department of Anatomy and Cell Biology, College of Medicine, Hanyang UniversityLaboratory of Autoimmunology, Department of Anatomy and Cell Biology, College of Medicine, Hanyang UniversityDepartment of Pathology, College of Medicine, Hanyang UniversityDepartment of Pathology, College of Medicine, Hanyang UniversityDepartment of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, Gachon UniversityLaboratory of Autoimmunology, Department of Anatomy and Cell Biology, College of Medicine, Hanyang UniversityLaboratory of Autoimmunology, Department of Anatomy and Cell Biology, College of Medicine, Hanyang UniversityAutoimmune disease: Bach2 orchestrates immune function Bach2, a protein that regulates gene expression, is required in the B cells and T cells of the immune system to protect against autoimmune disease. Bach2 deficiency has previously been associated with systemic lupus erythematosus (SLE), but the mechanisms through which it contributes to the development of an immune response against healthy tissue in many parts of the body were unclear. Jeehee Youn at Hanyang University in Seoul, South Korea, and colleagues showed that B cells from mice lacking Bach2 produce self-reactive antibodies and express SLE-related genes. Furthermore, when they specifically deleted Bach2 in T cells, they found that it triggered differentiation into a type of T cell which promoted the maturation of self-reactive B cells. The authors conclude that Bach2 activity in both B cells and T cells is key to maintaining immune self-tolerance.https://doi.org/10.1038/s12276-019-0352-x |
| spellingShingle | Eunkyeong Jang Un Kyo Kim Kiseok Jang Young Soo Song Ji-Young Cha Hansol Yi Jeehee Youn Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway Experimental and Molecular Medicine |
| title | Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway |
| title_full | Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway |
| title_fullStr | Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway |
| title_full_unstemmed | Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway |
| title_short | Bach2 deficiency leads autoreactive B cells to produce IgG autoantibodies and induce lupus through a T cell-dependent extrafollicular pathway |
| title_sort | bach2 deficiency leads autoreactive b cells to produce igg autoantibodies and induce lupus through a t cell dependent extrafollicular pathway |
| url | https://doi.org/10.1038/s12276-019-0352-x |
| work_keys_str_mv | AT eunkyeongjang bach2deficiencyleadsautoreactivebcellstoproduceiggautoantibodiesandinducelupusthroughatcelldependentextrafollicularpathway AT unkyokim bach2deficiencyleadsautoreactivebcellstoproduceiggautoantibodiesandinducelupusthroughatcelldependentextrafollicularpathway AT kiseokjang bach2deficiencyleadsautoreactivebcellstoproduceiggautoantibodiesandinducelupusthroughatcelldependentextrafollicularpathway AT youngsoosong bach2deficiencyleadsautoreactivebcellstoproduceiggautoantibodiesandinducelupusthroughatcelldependentextrafollicularpathway AT jiyoungcha bach2deficiencyleadsautoreactivebcellstoproduceiggautoantibodiesandinducelupusthroughatcelldependentextrafollicularpathway AT hansolyi bach2deficiencyleadsautoreactivebcellstoproduceiggautoantibodiesandinducelupusthroughatcelldependentextrafollicularpathway AT jeeheeyoun bach2deficiencyleadsautoreactivebcellstoproduceiggautoantibodiesandinducelupusthroughatcelldependentextrafollicularpathway |