Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents

Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents

The transcription factor PU.1 (Purine-rich DNA binding, SPI1) is a key regulator of hematopoiesis, whose level is influenced by transcription through its enhancers and its post-transcriptional degradation via microRNA-155 (miR-155). The degree of transcriptional regulation of the <i>PU.1</i...

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Bibliographic Details
Main Authors: Petra Bašová, Helena Paszeková, Lubomír Minařík, Martina Dluhošová, Pavel Burda, Tomáš Stopka
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
transcription factor PU.1
microRNA miR-155
5-Azacytidine
Celastrol
Online Access:https://www.mdpi.com/1422-0067/23/12/6729

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