Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors
Background: The incidence of pancreatic neuroendocrine tumors (PNETs) has increased significantly. The purpose of this study was to analyze the clinical characteristics and prognosis of patients under 50 years old. Methods: Patients with PNETs recorded in the Surveillance, Epidemiology, and End Resu...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-01-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/1073274820986827 |
| _version_ | 1819075634175934464 |
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| author | Min Shi Biao Zhou |
| author_facet | Min Shi Biao Zhou |
| author_sort | Min Shi |
| collection | DOAJ |
| description | Background: The incidence of pancreatic neuroendocrine tumors (PNETs) has increased significantly. The purpose of this study was to analyze the clinical characteristics and prognosis of patients under 50 years old. Methods: Patients with PNETs recorded in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015 were analyzed. The clinical characteristics were analyzed by Chi-square test. The Kaplan-Meier method was used to estimate overall survival (OS). Multivariate Cox proportional risk regression analysis was used to determine independent prognostic factors. Results: 2,303 patients included, of which 547 (23.8%) patients were younger than 50 years old. The number of younger patients has increased steadily, while the proportion in total PNETs decreased recently. Compared with older group, the proportion of the Black, grade I/II, and surgery were higher in early-onset PNETs. Liver was the most frequent metastatic site. There was no significant difference in the incidence of different metastatic sites between younger and older PNETs patients, while younger patients had better OS (P < 0.05). Grade, N stage, M stage, and surgery were independent prognostic factors for OS in early-onset PNETs. Conclusions: Younger patients have unique clinicopathological characteristics compared with older patients in PNETs. Better OS was observed in younger patients which might due to the higher proportion of well-differentiated tumor and surgery than older patients. |
| first_indexed | 2024-12-21T18:28:31Z |
| format | Article |
| id | doaj.art-693de206bd794d618210b7e269c0faa7 |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-12-21T18:28:31Z |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-693de206bd794d618210b7e269c0faa72022-12-21T18:54:20ZengSAGE PublishingCancer Control1073-27482021-01-012810.1177/1073274820986827Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine TumorsMin Shi0Biao Zhou1 Department of Gastroenterology, Liyang People’s Hospital, Liyang City, Jiangsu, China Department of Gastroenterology, Liyang People’s Hospital, Liyang City, Jiangsu, ChinaBackground: The incidence of pancreatic neuroendocrine tumors (PNETs) has increased significantly. The purpose of this study was to analyze the clinical characteristics and prognosis of patients under 50 years old. Methods: Patients with PNETs recorded in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015 were analyzed. The clinical characteristics were analyzed by Chi-square test. The Kaplan-Meier method was used to estimate overall survival (OS). Multivariate Cox proportional risk regression analysis was used to determine independent prognostic factors. Results: 2,303 patients included, of which 547 (23.8%) patients were younger than 50 years old. The number of younger patients has increased steadily, while the proportion in total PNETs decreased recently. Compared with older group, the proportion of the Black, grade I/II, and surgery were higher in early-onset PNETs. Liver was the most frequent metastatic site. There was no significant difference in the incidence of different metastatic sites between younger and older PNETs patients, while younger patients had better OS (P < 0.05). Grade, N stage, M stage, and surgery were independent prognostic factors for OS in early-onset PNETs. Conclusions: Younger patients have unique clinicopathological characteristics compared with older patients in PNETs. Better OS was observed in younger patients which might due to the higher proportion of well-differentiated tumor and surgery than older patients.https://doi.org/10.1177/1073274820986827 |
| spellingShingle | Min Shi Biao Zhou Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors Cancer Control |
| title | Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors |
| title_full | Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors |
| title_fullStr | Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors |
| title_full_unstemmed | Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors |
| title_short | Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors |
| title_sort | clinical characteristics and prognostic factors of early onset pancreatic neuroendocrine tumors |
| url | https://doi.org/10.1177/1073274820986827 |
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