Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine
Abstract The humoral response after the fourth dose of a mRNA vaccine against COVID-19 has not been adequately described in elderly recipients, particularly those not exposed previously to SARS-CoV-2. Serum anti-RBD IgG levels (Abbott SARS-CoV-2 IgG II Quant assay) and neutralizing capacities (spike...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41399-5 |
| _version_ | 1797452721744248832 |
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| author | Alexander Rouvinski Ahuva Friedman Saveliy Kirillov Jordan Hannink Attal Sujata Kumari Jamal Fahoum Reuven Wiener Sophie Magen Yevgeni Plotkin Daniel Chemtob Herve Bercovier |
| author_facet | Alexander Rouvinski Ahuva Friedman Saveliy Kirillov Jordan Hannink Attal Sujata Kumari Jamal Fahoum Reuven Wiener Sophie Magen Yevgeni Plotkin Daniel Chemtob Herve Bercovier |
| author_sort | Alexander Rouvinski |
| collection | DOAJ |
| description | Abstract The humoral response after the fourth dose of a mRNA vaccine against COVID-19 has not been adequately described in elderly recipients, particularly those not exposed previously to SARS-CoV-2. Serum anti-RBD IgG levels (Abbott SARS-CoV-2 IgG II Quant assay) and neutralizing capacities (spike SARS-CoV-2 pseudovirus Wuhan and Omicron BA.1 variant) were measured after the third and fourth doses of a COVID-19 mRNA vaccine among 46 elderly residents (median age 85 years [IQR 81; 89]) of an assisted living facility. Among participants never infected by SARS-CoV-2, the mean serum IgG levels against RBD (2025 BAU/ml), 99 days after the fourth vaccine, was as high as 76 days after the third vaccine (1987 BAU/ml), and significantly higher (p = 0.030) when the latter were corrected for elapsed time. Neutralizing antibody levels against the historical Wuhan strain were significantly higher (Mean 1046 vs 1573; p = 0.002) and broader (against Omicron) (Mean 170 vs 375; p = 0.018), following the fourth vaccine. The six individuals with an Omicron breakthrough infection mounted strong immune responses for anti-RBD and neutralizing antibodies against the Omicron variant indicating that the fourth vaccine dose did not prevent a specific adaptation of the immune response. These findings point out the value of continued vaccine boosting in the elderly population |
| first_indexed | 2024-03-09T15:12:45Z |
| format | Article |
| id | doaj.art-69404afee59e494c9a707e00d24eb698 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:12:45Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-69404afee59e494c9a707e00d24eb6982023-11-26T13:17:39ZengNature PortfolioScientific Reports2045-23222023-08-0113111110.1038/s41598-023-41399-5Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccineAlexander Rouvinski0Ahuva Friedman1Saveliy Kirillov2Jordan Hannink Attal3Sujata Kumari4Jamal Fahoum5Reuven Wiener6Sophie Magen7Yevgeni Plotkin8Daniel Chemtob9Herve Bercovier10Department of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of JerusalemDepartment of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of JerusalemDepartment of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of JerusalemBraun School of Public Health and Community Medicine, Faculty of Medicine, Hebrew University of JerusalemDepartment of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of JerusalemDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Hebrew University of JerusalemDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Hebrew University of JerusalemDepartment of Clinical Biochemistry, Shaare Zedek Medical CenterDepartment of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Center and Faculty of Medicine, Hebrew University of JerusalemBraun School of Public Health and Community Medicine, Faculty of Medicine, Hebrew University of JerusalemDepartment of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University of JerusalemAbstract The humoral response after the fourth dose of a mRNA vaccine against COVID-19 has not been adequately described in elderly recipients, particularly those not exposed previously to SARS-CoV-2. Serum anti-RBD IgG levels (Abbott SARS-CoV-2 IgG II Quant assay) and neutralizing capacities (spike SARS-CoV-2 pseudovirus Wuhan and Omicron BA.1 variant) were measured after the third and fourth doses of a COVID-19 mRNA vaccine among 46 elderly residents (median age 85 years [IQR 81; 89]) of an assisted living facility. Among participants never infected by SARS-CoV-2, the mean serum IgG levels against RBD (2025 BAU/ml), 99 days after the fourth vaccine, was as high as 76 days after the third vaccine (1987 BAU/ml), and significantly higher (p = 0.030) when the latter were corrected for elapsed time. Neutralizing antibody levels against the historical Wuhan strain were significantly higher (Mean 1046 vs 1573; p = 0.002) and broader (against Omicron) (Mean 170 vs 375; p = 0.018), following the fourth vaccine. The six individuals with an Omicron breakthrough infection mounted strong immune responses for anti-RBD and neutralizing antibodies against the Omicron variant indicating that the fourth vaccine dose did not prevent a specific adaptation of the immune response. These findings point out the value of continued vaccine boosting in the elderly populationhttps://doi.org/10.1038/s41598-023-41399-5 |
| spellingShingle | Alexander Rouvinski Ahuva Friedman Saveliy Kirillov Jordan Hannink Attal Sujata Kumari Jamal Fahoum Reuven Wiener Sophie Magen Yevgeni Plotkin Daniel Chemtob Herve Bercovier Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine Scientific Reports |
| title | Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine |
| title_full | Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine |
| title_fullStr | Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine |
| title_full_unstemmed | Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine |
| title_short | Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine |
| title_sort | antibody response in elderly vaccinated four times with an mrna anti covid 19 vaccine |
| url | https://doi.org/10.1038/s41598-023-41399-5 |
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