Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV
After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/2/244 |
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| author | Jiabao Xu Shizhe Zhao Tieshan Teng Abualgasim Elgaili Abdalla Wan Zhu Longxiang Xie Yunlong Wang Xiangqian Guo |
| author_facet | Jiabao Xu Shizhe Zhao Tieshan Teng Abualgasim Elgaili Abdalla Wan Zhu Longxiang Xie Yunlong Wang Xiangqian Guo |
| author_sort | Jiabao Xu |
| collection | DOAJ |
| description | After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as “coronavirus disease 2019” (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms. |
| first_indexed | 2024-12-18T06:48:19Z |
| format | Article |
| id | doaj.art-6941d0cf3eb14b6381ddf031e9098039 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-18T06:48:19Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-6941d0cf3eb14b6381ddf031e90980392022-12-21T21:17:25ZengMDPI AGViruses1999-49152020-02-0112224410.3390/v12020244v12020244Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoVJiabao Xu0Shizhe Zhao1Tieshan Teng2Abualgasim Elgaili Abdalla3Wan Zhu4Longxiang Xie5Yunlong Wang6Xiangqian Guo7Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaDepartment of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaDepartment of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 2014, Saudi ArabiaDepartment of Anesthesia, Stanford University, Stanford, CA 94305, USADepartment of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaHenan Bioengineering Research Center, Zhengzhou 450046, ChinaDepartment of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng 475004, ChinaAfter the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as “coronavirus disease 2019” (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms.https://www.mdpi.com/1999-4915/12/2/244coronavirusessars-cov-2sars-covgenomic comparisonproteomic comparisonpathogenic mechanismclinical manifestations |
| spellingShingle | Jiabao Xu Shizhe Zhao Tieshan Teng Abualgasim Elgaili Abdalla Wan Zhu Longxiang Xie Yunlong Wang Xiangqian Guo Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV Viruses coronaviruses sars-cov-2 sars-cov genomic comparison proteomic comparison pathogenic mechanism clinical manifestations |
| title | Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV |
| title_full | Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV |
| title_fullStr | Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV |
| title_full_unstemmed | Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV |
| title_short | Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV |
| title_sort | systematic comparison of two animal to human transmitted human coronaviruses sars cov 2 and sars cov |
| topic | coronaviruses sars-cov-2 sars-cov genomic comparison proteomic comparison pathogenic mechanism clinical manifestations |
| url | https://www.mdpi.com/1999-4915/12/2/244 |
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