Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin Microflora
The human forearm skin microbiome ecosystem contains rich and diverse microbes, which are influenced by environmental exposures. The microbial representatives can be exchanged between human and environment, specifically animals, by which they share certain or similar epidermal microbes. Livestock an...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/10/1481 |
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| author | Mengfei Peng Debabrata Biswas |
| author_facet | Mengfei Peng Debabrata Biswas |
| author_sort | Mengfei Peng |
| collection | DOAJ |
| description | The human forearm skin microbiome ecosystem contains rich and diverse microbes, which are influenced by environmental exposures. The microbial representatives can be exchanged between human and environment, specifically animals, by which they share certain or similar epidermal microbes. Livestock and poultry are the microbial sources that are associated with the transmission of community-based pathogenic infections. Here, in this study, we proposed investigating the environmental influences introduced by livestock/poultry operations on forearm skin microflora of on-site farm workers. A total of 30 human skin swab samples were collected from 20 animal workers in dairy or integrated farms and 10 healthy volunteer controls. The skin microbiome was 16S metagenomics that were sequenced with Illumina MiSeq system. For skin microbial community analysis, the abundance of major phyla and genera as well as alpha and beta diversities were compared across groups. We identified distinctive microbial compositional patterns on skin of workers in farm with different animal commodities. Workers in integrated farms containing various animals were associated with higher abundances of epidermal Proteobacteria, especially <i>Pseudomonas</i> and <i>Acinetobacter</i>, but lower Actinobacteria, especially <i>Corynebacterium</i> and <i>Propionibacterium</i>. For those workers with frequent dairy cattle operations, their Firmicutes in the forearm skin microbiota were enriched. Furthermore, farm animal operations also reduced <i>Staphylococcus</i> and <i>Streptococcus</i>, as well as modulated the microbial biodiversity in farm workers’ skin microbiome. The alterations of forearm skin microflora in farm workers, influenced by their frequent farm animal operations, may increase their risk in skin infections with unusual pathogens and epidermal diseases. |
| first_indexed | 2024-03-10T16:01:44Z |
| format | Article |
| id | doaj.art-694230c5ca6c4f5dafa5f4fd2e766848 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T16:01:44Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-694230c5ca6c4f5dafa5f4fd2e7668482023-11-20T15:14:14ZengMDPI AGMicroorganisms2076-26072020-09-01810148110.3390/microorganisms8101481Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin MicrofloraMengfei Peng0Debabrata Biswas1Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USADepartment of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USAThe human forearm skin microbiome ecosystem contains rich and diverse microbes, which are influenced by environmental exposures. The microbial representatives can be exchanged between human and environment, specifically animals, by which they share certain or similar epidermal microbes. Livestock and poultry are the microbial sources that are associated with the transmission of community-based pathogenic infections. Here, in this study, we proposed investigating the environmental influences introduced by livestock/poultry operations on forearm skin microflora of on-site farm workers. A total of 30 human skin swab samples were collected from 20 animal workers in dairy or integrated farms and 10 healthy volunteer controls. The skin microbiome was 16S metagenomics that were sequenced with Illumina MiSeq system. For skin microbial community analysis, the abundance of major phyla and genera as well as alpha and beta diversities were compared across groups. We identified distinctive microbial compositional patterns on skin of workers in farm with different animal commodities. Workers in integrated farms containing various animals were associated with higher abundances of epidermal Proteobacteria, especially <i>Pseudomonas</i> and <i>Acinetobacter</i>, but lower Actinobacteria, especially <i>Corynebacterium</i> and <i>Propionibacterium</i>. For those workers with frequent dairy cattle operations, their Firmicutes in the forearm skin microbiota were enriched. Furthermore, farm animal operations also reduced <i>Staphylococcus</i> and <i>Streptococcus</i>, as well as modulated the microbial biodiversity in farm workers’ skin microbiome. The alterations of forearm skin microflora in farm workers, influenced by their frequent farm animal operations, may increase their risk in skin infections with unusual pathogens and epidermal diseases.https://www.mdpi.com/2076-2607/8/10/1481human skin microbiomefarm animaldysbiosismicrobial diversitymetagenomics |
| spellingShingle | Mengfei Peng Debabrata Biswas Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin Microflora Microorganisms human skin microbiome farm animal dysbiosis microbial diversity metagenomics |
| title | Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin Microflora |
| title_full | Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin Microflora |
| title_fullStr | Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin Microflora |
| title_full_unstemmed | Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin Microflora |
| title_short | Environmental Influences of High-Density Agricultural Animal Operation on Human Forearm Skin Microflora |
| title_sort | environmental influences of high density agricultural animal operation on human forearm skin microflora |
| topic | human skin microbiome farm animal dysbiosis microbial diversity metagenomics |
| url | https://www.mdpi.com/2076-2607/8/10/1481 |
| work_keys_str_mv | AT mengfeipeng environmentalinfluencesofhighdensityagriculturalanimaloperationonhumanforearmskinmicroflora AT debabratabiswas environmentalinfluencesofhighdensityagriculturalanimaloperationonhumanforearmskinmicroflora |