Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination.
PURPOSE:The aim of this study was to derive reference values of 18F-fluoro-ethyl-L-tyrosine positron emission tomography (18F-FET-PET) uptake in normal brain and head structures to allow for differentiation from tumor tissue. MATERIALS AND METHODS:We examined the datasets of 70 patients (median age...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0230618 |
| _version_ | 1819017093527371776 |
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| author | Brigitte Fuenfgeld Philipp Mächler Dorothee R Fischer Giuseppe Esposito Elisabeth Jane Rushing Philipp A Kaufmann Paul Stolzmann Martin W Huellner |
| author_facet | Brigitte Fuenfgeld Philipp Mächler Dorothee R Fischer Giuseppe Esposito Elisabeth Jane Rushing Philipp A Kaufmann Paul Stolzmann Martin W Huellner |
| author_sort | Brigitte Fuenfgeld |
| collection | DOAJ |
| description | PURPOSE:The aim of this study was to derive reference values of 18F-fluoro-ethyl-L-tyrosine positron emission tomography (18F-FET-PET) uptake in normal brain and head structures to allow for differentiation from tumor tissue. MATERIALS AND METHODS:We examined the datasets of 70 patients (median age 53 years, range 15-79), whose dynamic 18F-FET-PET was acquired between January 2016 and October 2017. Maximum standardized uptake value (SUVmax), target-to-background standardized uptake value ratio (TBR), and time activity curve (TAC) of the 18F-FET-PET were assessed in tumor tissue and in eight normal anatomic structures and compared using the t-test and Mann-Whitney U-test. Correlation analyses were performed using Pearson or Spearman coefficients, and comparisons between several variables with Pearson's chi-squared tests and Kruskal-Wallis tests as well as the Benjamini-Hochberg correction. RESULTS:All analyzed structures showed an 18F-FET uptake higher than background (threshold: TBR > 1.5). The venous sinuses and cranial muscles exhibited a TBR of 2.03±0.46 (confidence interval (CI) 1.92-2.14), higher than the uptake of caudate nucleus, pineal gland, putamen, and thalamus (TBR 1.42±0.17, CI 1.38-1.47). SUVmax, TBR, and TAC showed no difference in the analyzed structures between subjects with high-grade gliomas and subjects with low-grade gliomas, except the SUVmax of the pineal gland (t-tests of the pineal gland: SUVmax: p = 0.022; TBR: p = 0.411). No significant differences were found for gender and age. CONCLUSION:Normal brain tissue demonstrates increased 18F-FET uptake compared to background tissue. Two distinct clusters have been identified, comprising venous structures and gray matter with a reference uptake of up to SUVmax of 2.99 and 2.33, respectively. |
| first_indexed | 2024-12-21T02:58:03Z |
| format | Article |
| id | doaj.art-6942f5fcc6be4921be0ca1d25280670f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T02:58:03Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6942f5fcc6be4921be0ca1d25280670f2022-12-21T19:18:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01154e023061810.1371/journal.pone.0230618Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination.Brigitte FuenfgeldPhilipp MächlerDorothee R FischerGiuseppe EspositoElisabeth Jane RushingPhilipp A KaufmannPaul StolzmannMartin W HuellnerPURPOSE:The aim of this study was to derive reference values of 18F-fluoro-ethyl-L-tyrosine positron emission tomography (18F-FET-PET) uptake in normal brain and head structures to allow for differentiation from tumor tissue. MATERIALS AND METHODS:We examined the datasets of 70 patients (median age 53 years, range 15-79), whose dynamic 18F-FET-PET was acquired between January 2016 and October 2017. Maximum standardized uptake value (SUVmax), target-to-background standardized uptake value ratio (TBR), and time activity curve (TAC) of the 18F-FET-PET were assessed in tumor tissue and in eight normal anatomic structures and compared using the t-test and Mann-Whitney U-test. Correlation analyses were performed using Pearson or Spearman coefficients, and comparisons between several variables with Pearson's chi-squared tests and Kruskal-Wallis tests as well as the Benjamini-Hochberg correction. RESULTS:All analyzed structures showed an 18F-FET uptake higher than background (threshold: TBR > 1.5). The venous sinuses and cranial muscles exhibited a TBR of 2.03±0.46 (confidence interval (CI) 1.92-2.14), higher than the uptake of caudate nucleus, pineal gland, putamen, and thalamus (TBR 1.42±0.17, CI 1.38-1.47). SUVmax, TBR, and TAC showed no difference in the analyzed structures between subjects with high-grade gliomas and subjects with low-grade gliomas, except the SUVmax of the pineal gland (t-tests of the pineal gland: SUVmax: p = 0.022; TBR: p = 0.411). No significant differences were found for gender and age. CONCLUSION:Normal brain tissue demonstrates increased 18F-FET uptake compared to background tissue. Two distinct clusters have been identified, comprising venous structures and gray matter with a reference uptake of up to SUVmax of 2.99 and 2.33, respectively.https://doi.org/10.1371/journal.pone.0230618 |
| spellingShingle | Brigitte Fuenfgeld Philipp Mächler Dorothee R Fischer Giuseppe Esposito Elisabeth Jane Rushing Philipp A Kaufmann Paul Stolzmann Martin W Huellner Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination. PLoS ONE |
| title | Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination. |
| title_full | Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination. |
| title_fullStr | Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination. |
| title_full_unstemmed | Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination. |
| title_short | Reference values of physiological 18F-FET uptake: Implications for brain tumor discrimination. |
| title_sort | reference values of physiological 18f fet uptake implications for brain tumor discrimination |
| url | https://doi.org/10.1371/journal.pone.0230618 |
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