Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots
The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/Zn...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12514 |
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| author | Vuyelwa Ncapayi Neethu Ninan Thabang C. Lebepe Sundararajan Parani Aswathy Ravindran Girija Richard Bright Krasimir Vasilev Rodney Maluleke Ncediwe Tsolekile Tetsuya Kodama Oluwatobi S. Oluwafemi |
| author_facet | Vuyelwa Ncapayi Neethu Ninan Thabang C. Lebepe Sundararajan Parani Aswathy Ravindran Girija Richard Bright Krasimir Vasilev Rodney Maluleke Ncediwe Tsolekile Tetsuya Kodama Oluwatobi S. Oluwafemi |
| author_sort | Vuyelwa Ncapayi |
| collection | DOAJ |
| description | The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in <i>Staphylococcus aureus</i>, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer. |
| first_indexed | 2024-03-10T05:25:38Z |
| format | Article |
| id | doaj.art-69447d3c27c04eb1ae628ce32be2da5b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:25:38Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-69447d3c27c04eb1ae628ce32be2da5b2023-11-22T23:43:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221251410.3390/ijms222212514Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum DotsVuyelwa Ncapayi0Neethu Ninan1Thabang C. Lebepe2Sundararajan Parani3Aswathy Ravindran Girija4Richard Bright5Krasimir Vasilev6Rodney Maluleke7Ncediwe Tsolekile8Tetsuya Kodama9Oluwatobi S. Oluwafemi10Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South AfricaAcademic Unit of STEM, University of South Australia, Mawson Lakes, SA 5095, AustraliaDepartment of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South AfricaDepartment of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South AfricaFuture Industries Institute, University of South Australia, Mawson Lakes, SA 5095, AustraliaAcademic Unit of STEM, University of South Australia, Mawson Lakes, SA 5095, AustraliaAcademic Unit of STEM, University of South Australia, Mawson Lakes, SA 5095, AustraliaDepartment of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South AfricaDepartment of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South AfricaDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanDepartment of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South AfricaThe link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in <i>Staphylococcus aureus</i>, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.https://www.mdpi.com/1422-0067/22/22/12514near infra-red quantum dotsbioimagingprostate cancerGram-positive bacteriaGram-negative bacteria |
| spellingShingle | Vuyelwa Ncapayi Neethu Ninan Thabang C. Lebepe Sundararajan Parani Aswathy Ravindran Girija Richard Bright Krasimir Vasilev Rodney Maluleke Ncediwe Tsolekile Tetsuya Kodama Oluwatobi S. Oluwafemi Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots International Journal of Molecular Sciences near infra-red quantum dots bioimaging prostate cancer Gram-positive bacteria Gram-negative bacteria |
| title | Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots |
| title_full | Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots |
| title_fullStr | Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots |
| title_full_unstemmed | Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots |
| title_short | Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots |
| title_sort | diagnosis of prostate cancer and prostatitis using near infra red fluorescent aginse zns quantum dots |
| topic | near infra-red quantum dots bioimaging prostate cancer Gram-positive bacteria Gram-negative bacteria |
| url | https://www.mdpi.com/1422-0067/22/22/12514 |
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