The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult Rats
Background & objectives: Diet plays an important role in control of seizure in epileptic patients. Therefore in this research, the effect of acute and chronic sesame oil consumption on the seizure induced by strychnine in adult rats was investigated. Methods: In this experimental study, forty -t...
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| Format: | Article |
| Language: | fas |
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Ardabil University of Medical Sciences
2019-03-01
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| Series: | Journal of Ardabil University of Medical Sciences |
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| Online Access: | http://jarums.arums.ac.ir/browse.php?a_code=A-10-1246-1&slc_lang=en&sid=1 |
| _version_ | 1818848071529791488 |
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| author | Raha zalkhani Hossein Najafzadehvarzi Ahmad Ali Moazedi |
| author_facet | Raha zalkhani Hossein Najafzadehvarzi Ahmad Ali Moazedi |
| author_sort | Raha zalkhani |
| collection | DOAJ |
| description | Background & objectives: Diet plays an important role in control of seizure in epileptic patients. Therefore in this research, the effect of acute and chronic sesame oil consumption on the seizure induced by strychnine in adult rats was investigated.
Methods: In this experimental study, forty -two rats were divided into six groups: control (saline recipient, 1 ml/kg (, acute recipients of sodium valproate as positive control group (100 or 200 mg/kg, ip.), acute recipients of sesame oil (0.75 or 1.5 ml/kg, ip.) and chronic recipient of sesame oil (1.5 ml/kg/day, orally, 21 days). To induce seizure, strychnine was injected intraperitoneally 30 minutes after receiving saline, valproate or oil. Then seizure onset time and death time were recorded within 30 minutes.
Results: Acute injection of sesame oil increased seizure onset time and death time compared to control group but it was no significantly different. The chronic consumption of sesame oil significantly increased seizure onset time (p=0.029) in compared to control group, but there was no effect on the death time. Also, there were no significant differences in seizure onset time and death time between acute and chronic groups.
Conclusion: It seems that chronic consumption of sesame oil delayed the onset of seizure and reduced the kindled seizure acquisition. |
| first_indexed | 2024-12-19T06:11:31Z |
| format | Article |
| id | doaj.art-69453a7361f84efc91de78134e23f230 |
| institution | Directory Open Access Journal |
| issn | 2228-7280 2228-7299 |
| language | fas |
| last_indexed | 2024-12-19T06:11:31Z |
| publishDate | 2019-03-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj.art-69453a7361f84efc91de78134e23f2302022-12-21T20:32:59ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992019-03-01184470478The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult RatsRaha zalkhani0Hossein Najafzadehvarzi1Ahmad Ali Moazedi2 Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Department of pharmacology, Faculty of veterinary medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Background & objectives: Diet plays an important role in control of seizure in epileptic patients. Therefore in this research, the effect of acute and chronic sesame oil consumption on the seizure induced by strychnine in adult rats was investigated. Methods: In this experimental study, forty -two rats were divided into six groups: control (saline recipient, 1 ml/kg (, acute recipients of sodium valproate as positive control group (100 or 200 mg/kg, ip.), acute recipients of sesame oil (0.75 or 1.5 ml/kg, ip.) and chronic recipient of sesame oil (1.5 ml/kg/day, orally, 21 days). To induce seizure, strychnine was injected intraperitoneally 30 minutes after receiving saline, valproate or oil. Then seizure onset time and death time were recorded within 30 minutes. Results: Acute injection of sesame oil increased seizure onset time and death time compared to control group but it was no significantly different. The chronic consumption of sesame oil significantly increased seizure onset time (p=0.029) in compared to control group, but there was no effect on the death time. Also, there were no significant differences in seizure onset time and death time between acute and chronic groups. Conclusion: It seems that chronic consumption of sesame oil delayed the onset of seizure and reduced the kindled seizure acquisition.http://jarums.arums.ac.ir/browse.php?a_code=A-10-1246-1&slc_lang=en&sid=1StrychnineSesame OilSeizureRat |
| spellingShingle | Raha zalkhani Hossein Najafzadehvarzi Ahmad Ali Moazedi The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult Rats Journal of Ardabil University of Medical Sciences Strychnine Sesame Oil Seizure Rat |
| title | The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult Rats |
| title_full | The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult Rats |
| title_fullStr | The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult Rats |
| title_full_unstemmed | The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult Rats |
| title_short | The Effect of Acute and Chronic Sesame Oil Consumption on the Strychnine Induced Seizure in Adult Rats |
| title_sort | effect of acute and chronic sesame oil consumption on the strychnine induced seizure in adult rats |
| topic | Strychnine Sesame Oil Seizure Rat |
| url | http://jarums.arums.ac.ir/browse.php?a_code=A-10-1246-1&slc_lang=en&sid=1 |
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