Antibiotic-driven escape of host in a parasite-induced Red Queen dynamics
Winnerless coevolution of hosts and parasites could exhibit Red Queen dynamics, which is characterized by parasite-driven cyclic switching of expressed host phenotypes. We hypothesize that the application of antibiotics to suppress the reproduction of parasites can provide an opportunity for the hos...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2018-01-01
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| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180693 |
| _version_ | 1818417693670244352 |
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| author | Elizabeth L. Anzia Jomar F. Rabajante |
| author_facet | Elizabeth L. Anzia Jomar F. Rabajante |
| author_sort | Elizabeth L. Anzia |
| collection | DOAJ |
| description | Winnerless coevolution of hosts and parasites could exhibit Red Queen dynamics, which is characterized by parasite-driven cyclic switching of expressed host phenotypes. We hypothesize that the application of antibiotics to suppress the reproduction of parasites can provide an opportunity for the hosts to escape such winnerless coevolution. Here, we formulate a minimal mathematical model of host–parasite interaction involving multiple host phenotypes that are targeted by adapting parasites. Our model predicts the levels of antibiotic effectiveness that can steer the parasite-driven cyclic switching of host phenotypes (oscillations) to a stable equilibrium of host survival. Our simulations show that uninterrupted application of antibiotic with high-level effectiveness (greater than 85%) is needed to escape the Red Queen dynamics. Interrupted and low level of antibiotic effectiveness are indeed useless to stop host–parasite coevolution. This study can be a guide in designing good practices and protocols to minimize the risk of further progression of parasitic infections. |
| first_indexed | 2024-12-14T12:10:50Z |
| format | Article |
| id | doaj.art-6945f256464d4fb9a2ce1d4959fe008e |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-14T12:10:50Z |
| publishDate | 2018-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-6945f256464d4fb9a2ce1d4959fe008e2022-12-21T23:01:45ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015910.1098/rsos.180693180693Antibiotic-driven escape of host in a parasite-induced Red Queen dynamicsElizabeth L. AnziaJomar F. RabajanteWinnerless coevolution of hosts and parasites could exhibit Red Queen dynamics, which is characterized by parasite-driven cyclic switching of expressed host phenotypes. We hypothesize that the application of antibiotics to suppress the reproduction of parasites can provide an opportunity for the hosts to escape such winnerless coevolution. Here, we formulate a minimal mathematical model of host–parasite interaction involving multiple host phenotypes that are targeted by adapting parasites. Our model predicts the levels of antibiotic effectiveness that can steer the parasite-driven cyclic switching of host phenotypes (oscillations) to a stable equilibrium of host survival. Our simulations show that uninterrupted application of antibiotic with high-level effectiveness (greater than 85%) is needed to escape the Red Queen dynamics. Interrupted and low level of antibiotic effectiveness are indeed useless to stop host–parasite coevolution. This study can be a guide in designing good practices and protocols to minimize the risk of further progression of parasitic infections.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180693red queen hypothesiscoevolutionantibiotic effectivenessantibiotic resistanceevolutionary parasitology |
| spellingShingle | Elizabeth L. Anzia Jomar F. Rabajante Antibiotic-driven escape of host in a parasite-induced Red Queen dynamics Royal Society Open Science red queen hypothesis coevolution antibiotic effectiveness antibiotic resistance evolutionary parasitology |
| title | Antibiotic-driven escape of host in a parasite-induced Red Queen dynamics |
| title_full | Antibiotic-driven escape of host in a parasite-induced Red Queen dynamics |
| title_fullStr | Antibiotic-driven escape of host in a parasite-induced Red Queen dynamics |
| title_full_unstemmed | Antibiotic-driven escape of host in a parasite-induced Red Queen dynamics |
| title_short | Antibiotic-driven escape of host in a parasite-induced Red Queen dynamics |
| title_sort | antibiotic driven escape of host in a parasite induced red queen dynamics |
| topic | red queen hypothesis coevolution antibiotic effectiveness antibiotic resistance evolutionary parasitology |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180693 |
| work_keys_str_mv | AT elizabethlanzia antibioticdrivenescapeofhostinaparasiteinducedredqueendynamics AT jomarfrabajante antibioticdrivenescapeofhostinaparasiteinducedredqueendynamics |