Mutual Effects of Single and Combined CFTR Modulators and Bacterial Infection in Cystic Fibrosis

Mutual Effects of Single and Combined CFTR Modulators and Bacterial Infection in Cystic Fibrosis

ABSTRACT Cystic fibrosis transmembrane conductance regulator (CFTR) modulators improve clinical outcomes with varied efficacies in patients with CF. However, the mutual effects of CFTR modulators and bacterial adaptation, together with antibiotic regimens, can influence clinical outcomes. We evaluat...

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Bibliographic Details
Main Authors: Cristina Cigana, Ruggero Giannella, Alice Colavolpe, Beatriz Alcalá-Franco, Giulia Mancini, Francesca Colombi, Chiara Bigogno, Ulla Bastrup, Giovanni Bertoni, Alessandra Bragonzi
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
cystic fibrosis
CFTR modulator
Pseudomonas aeruginosa
Staphylococcus aureus
antibiotic
murine model
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04083-22

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