Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties
Abstract Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and exploration of new fields of their applications are at the forefront of modern nanotechnology. The possibility of engineering water-soluble NPs has paved the way to their use in various basic and a...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-02-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-018-2457-x |
| _version_ | 1797710703133458432 |
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| author | Alyona Sukhanova Svetlana Bozrova Pavel Sokolov Mikhail Berestovoy Alexander Karaulov Igor Nabiev |
| author_facet | Alyona Sukhanova Svetlana Bozrova Pavel Sokolov Mikhail Berestovoy Alexander Karaulov Igor Nabiev |
| author_sort | Alyona Sukhanova |
| collection | DOAJ |
| description | Abstract Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and exploration of new fields of their applications are at the forefront of modern nanotechnology. The possibility of engineering water-soluble NPs has paved the way to their use in various basic and applied biomedical researches. At present, NPs are used in diagnosis for imaging of numerous molecular markers of genetic and autoimmune diseases, malignant tumors, and many other disorders. NPs are also used for targeted delivery of drugs to tissues and organs, with controllable parameters of drug release and accumulation. In addition, there are examples of the use of NPs as active components, e.g., photosensitizers in photodynamic therapy and in hyperthermic tumor destruction through NP incorporation and heating. However, a high toxicity of NPs for living organisms is a strong limiting factor that hinders their use in vivo. Current studies on toxic effects of NPs aimed at identifying the targets and mechanisms of their harmful effects are carried out in cell culture models; studies on the patterns of NP transport, accumulation, degradation, and elimination, in animal models. This review systematizes and summarizes available data on how the mechanisms of NP toxicity for living systems are related to their physical and chemical properties. |
| first_indexed | 2024-03-12T06:56:04Z |
| format | Article |
| id | doaj.art-694839c1a1f64a718fbd9acfc5697511 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T06:56:04Z |
| publishDate | 2018-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-694839c1a1f64a718fbd9acfc56975112023-09-03T00:03:29ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2018-02-0113112110.1186/s11671-018-2457-xDependence of Nanoparticle Toxicity on Their Physical and Chemical PropertiesAlyona Sukhanova0Svetlana Bozrova1Pavel Sokolov2Mikhail Berestovoy3Alexander Karaulov4Igor Nabiev5Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-ArdenneLaboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical UniversityLaboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-ArdenneAbstract Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and exploration of new fields of their applications are at the forefront of modern nanotechnology. The possibility of engineering water-soluble NPs has paved the way to their use in various basic and applied biomedical researches. At present, NPs are used in diagnosis for imaging of numerous molecular markers of genetic and autoimmune diseases, malignant tumors, and many other disorders. NPs are also used for targeted delivery of drugs to tissues and organs, with controllable parameters of drug release and accumulation. In addition, there are examples of the use of NPs as active components, e.g., photosensitizers in photodynamic therapy and in hyperthermic tumor destruction through NP incorporation and heating. However, a high toxicity of NPs for living organisms is a strong limiting factor that hinders their use in vivo. Current studies on toxic effects of NPs aimed at identifying the targets and mechanisms of their harmful effects are carried out in cell culture models; studies on the patterns of NP transport, accumulation, degradation, and elimination, in animal models. This review systematizes and summarizes available data on how the mechanisms of NP toxicity for living systems are related to their physical and chemical properties.http://link.springer.com/article/10.1186/s11671-018-2457-xNanoparticlesQuantum dotsNanotoxicitySurface chemistryTheranosticsImaging |
| spellingShingle | Alyona Sukhanova Svetlana Bozrova Pavel Sokolov Mikhail Berestovoy Alexander Karaulov Igor Nabiev Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties Nanoscale Research Letters Nanoparticles Quantum dots Nanotoxicity Surface chemistry Theranostics Imaging |
| title | Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties |
| title_full | Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties |
| title_fullStr | Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties |
| title_full_unstemmed | Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties |
| title_short | Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties |
| title_sort | dependence of nanoparticle toxicity on their physical and chemical properties |
| topic | Nanoparticles Quantum dots Nanotoxicity Surface chemistry Theranostics Imaging |
| url | http://link.springer.com/article/10.1186/s11671-018-2457-x |
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