Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal Study
Purpose: To report histopathological findings for different types of polymers proposed as support for a Pintucci-type keratoprosthesis. Methods: Six polymers, including three types of polyesters ( # 1-3), one type of polytetrafluoroethylene (PTFE, #...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Knowledge E
2019-07-01
|
| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/jovr.v14i3.4779 |
| _version_ | 1811192887186030592 |
|---|---|
| author | Saeed Rahmani Mozhgan Rezaei Kanavi Mohammad Ali Javadi |
| author_facet | Saeed Rahmani Mozhgan Rezaei Kanavi Mohammad Ali Javadi |
| author_sort | Saeed Rahmani |
| collection | DOAJ |
| description | Purpose: To report histopathological findings for different types of polymers proposed as support for a Pintucci-type keratoprosthesis.
Methods: Six polymers, including three types of polyesters (
#
1-3), one type of polytetrafluoroethylene (PTFE,
#
4), polyethylene (
#
5), and expanded polytetrafluoroethylene (ePTFE,
#
6) were evaluated. Four samples of each material were placed under the orbicularis oculi muscles of 12 rabbits. After five weeks, the samples were removed and evaluated histopathologically. Fibrovascular tissue ingrowths were investigated in terms of tissue penetration depth into the materials (graded as none, mild, moderate, and intense) and fibrovascular ingrowth area at the ultimate level of tissue penetrance. ImageJ software was used to calculate fibrovascular tissue area between the material fibers, and the mean area values were compared between the materials.
Results: Polyester materials
#
1 and
#
3 demonstrated intense fibrovascular tissue penetration with a large fibrovascular ingrowth area; no overt tissue ingrowth was observed into material #6. The mean area of penetrated fibrovascular tissues was significantly different between materials (
P
< 0.001). Materials
#
2,
#
4, and
#
5 showed moderate fibrovascular tissue ingrowth and the area of presented fibrovascular tissue at the paracentral parts of material
#
4 was significantly smaller than that of materials
#
1 (
P
= 0.02) and
#
3 (
P
= 0.01).
Conclusion: Two polyester materials that had relatively large pore sizes demonstrated a deep and large area of fibrovascular ingrowth. Given that material #3 is thicker and more consistent than material
#
1, the former can be used as the appropriate material for supporting the Pintucci-type keratoprosthesis. |
| first_indexed | 2024-04-11T23:58:28Z |
| format | Article |
| id | doaj.art-694916329c3641148f576839e6e41ec8 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T23:58:28Z |
| publishDate | 2019-07-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-694916329c3641148f576839e6e41ec82022-12-22T03:56:17ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2019-07-01141810.18502/jovr.v14i3.4779jovr.v14i3.4779Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal StudySaeed RahmaniMozhgan Rezaei KanaviMohammad Ali JavadiPurpose: To report histopathological findings for different types of polymers proposed as support for a Pintucci-type keratoprosthesis. Methods: Six polymers, including three types of polyesters ( # 1-3), one type of polytetrafluoroethylene (PTFE, # 4), polyethylene ( # 5), and expanded polytetrafluoroethylene (ePTFE, # 6) were evaluated. Four samples of each material were placed under the orbicularis oculi muscles of 12 rabbits. After five weeks, the samples were removed and evaluated histopathologically. Fibrovascular tissue ingrowths were investigated in terms of tissue penetration depth into the materials (graded as none, mild, moderate, and intense) and fibrovascular ingrowth area at the ultimate level of tissue penetrance. ImageJ software was used to calculate fibrovascular tissue area between the material fibers, and the mean area values were compared between the materials. Results: Polyester materials # 1 and # 3 demonstrated intense fibrovascular tissue penetration with a large fibrovascular ingrowth area; no overt tissue ingrowth was observed into material #6. The mean area of penetrated fibrovascular tissues was significantly different between materials ( P < 0.001). Materials # 2, # 4, and # 5 showed moderate fibrovascular tissue ingrowth and the area of presented fibrovascular tissue at the paracentral parts of material # 4 was significantly smaller than that of materials # 1 ( P = 0.02) and # 3 ( P = 0.01). Conclusion: Two polyester materials that had relatively large pore sizes demonstrated a deep and large area of fibrovascular ingrowth. Given that material #3 is thicker and more consistent than material # 1, the former can be used as the appropriate material for supporting the Pintucci-type keratoprosthesis.https://doi.org/10.18502/jovr.v14i3.4779Fibrovascular Tissue IngrowthKeratoprosthesisPintucciPolymer |
| spellingShingle | Saeed Rahmani Mozhgan Rezaei Kanavi Mohammad Ali Javadi Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal Study Journal of Ophthalmic & Vision Research Fibrovascular Tissue Ingrowth Keratoprosthesis Pintucci Polymer |
| title | Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal Study |
| title_full | Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal Study |
| title_fullStr | Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal Study |
| title_full_unstemmed | Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal Study |
| title_short | Histopathologic Evaluation of Polymer Supports for Pintucci-type Keratoprostheses: An Animal Study |
| title_sort | histopathologic evaluation of polymer supports for pintucci type keratoprostheses an animal study |
| topic | Fibrovascular Tissue Ingrowth Keratoprosthesis Pintucci Polymer |
| url | https://doi.org/10.18502/jovr.v14i3.4779 |
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