Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

Evolutionary innovations that enable organisms to colonize new ecological niches are rare compared to gradual evolutionary changes in existing traits. We discovered that key mutations in the gltA gene, which encodes citrate synthase (CS), occurred both before and after Escherichia coli gained the ab...

Full description

Bibliographic Details
Main Authors: Erik M Quandt, Jimmy Gollihar, Zachary D Blount, Andrew D Ellington, George Georgiou, Jeffrey E Barrick
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
evolutionary innovation
epistasis
experimental evolution
flux balance analysis
metabolic network
genetic basis of adaptation
Online Access:https://elifesciences.org/articles/09696

Internet

https://elifesciences.org/articles/09696

Similar Items