The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice

The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice

The endocannabinoid system (ECS) is an intercellular signalling mechanism that is present in the islets of Langerhans and plays a role in the modulation of insulin secretion and expansion of the β-cell mass. The downstream signalling pathways mediating these effects are poorly understood. Mammalian...

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Bibliographic Details
Main Authors: Francisco J. Bermudez-Silva, Silvana Y. Romero-Zerbo, Magalie Haissaguerre, Inmaculada Ruz-Maldonado, Said Lhamyani, Rajaa El Bekay, Antoine Tabarin, Giovanni Marsicano, Daniela Cota
Format: Article
Language:English
Published: The Company of Biologists 2016-01-01
Series:Disease Models & Mechanisms
Subjects:
Cannabinoids
Insulin secretion
Rapamycin
Rimonabant
Islets
CB1
S6K1
Online Access:http://dmm.biologists.org/content/9/1/51

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