Comparative pharmacology of a new recombinant FSH expressed by a human cell line
Recombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO) cells and, more recently, follitropin delta expressed in the human cell line PER.C6. These recombinant FSH proteins have distinct glycosylat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2017-07-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/6/5/297.full |
| _version_ | 1819057827721773056 |
|---|---|
| author | Wolfgang Koechling Daniel Plaksin Glenn E Croston Janni V Jeppesen Kirsten T Macklon Claus Yding Andersen |
| author_facet | Wolfgang Koechling Daniel Plaksin Glenn E Croston Janni V Jeppesen Kirsten T Macklon Claus Yding Andersen |
| author_sort | Wolfgang Koechling |
| collection | DOAJ |
| description | Recombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO) cells and, more recently, follitropin delta expressed in the human cell line PER.C6. These recombinant FSH proteins have distinct glycosylation, and have distinct pharmacokinetic and pharmacodynamic profiles in women. Comparative experiments demonstrated that follitropin delta and follitropin alfa displayed the same in vitro potency at the human FSH receptor, but varied in their pharmacokinetics in mouse and rat. While follitropin delta clearance from serum depended in part on the hepatic asialoglycoprotein receptor (ASGPR), follitropin alfa clearance was unaffected by ASGPR inhibition in rat or genetic ablation in mice. The distinct properties of follitropin delta and follitropin alfa are likely to contribute to the differing pharmacokinetic and pharmacodynamic profiles observed in women and to influence their efficacy in therapeutic protocols for the treatment of infertility. |
| first_indexed | 2024-12-21T13:45:30Z |
| format | Article |
| id | doaj.art-694a90018c9e49529fd82a9cf92d9a66 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-21T13:45:30Z |
| publishDate | 2017-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-694a90018c9e49529fd82a9cf92d9a662022-12-21T19:01:53ZengBioscientificaEndocrine Connections2049-36142049-36142017-07-016529730510.1530/EC-17-0067Comparative pharmacology of a new recombinant FSH expressed by a human cell lineWolfgang Koechling0Daniel Plaksin1Glenn E Croston2Janni V Jeppesen3Kirsten T Macklon4Claus Yding Andersen5Ferring Pharmaceuticals A/S, Copenhagen, DenmarkBio-Technology General Israel Ltd, Ferring Pharmaceuticals, Kiryat Malachi, IsraelCroston Consulting, San Diego, California, USAThe Laboratory of Reproductive Biology, The Department of Fertility at The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and The University of Copenhagen, Copenhagen, DenmarkThe Laboratory of Reproductive Biology, The Department of Fertility at The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and The University of Copenhagen, Copenhagen, DenmarkThe Laboratory of Reproductive Biology, The Department of Fertility at The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and The University of Copenhagen, Copenhagen, DenmarkRecombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO) cells and, more recently, follitropin delta expressed in the human cell line PER.C6. These recombinant FSH proteins have distinct glycosylation, and have distinct pharmacokinetic and pharmacodynamic profiles in women. Comparative experiments demonstrated that follitropin delta and follitropin alfa displayed the same in vitro potency at the human FSH receptor, but varied in their pharmacokinetics in mouse and rat. While follitropin delta clearance from serum depended in part on the hepatic asialoglycoprotein receptor (ASGPR), follitropin alfa clearance was unaffected by ASGPR inhibition in rat or genetic ablation in mice. The distinct properties of follitropin delta and follitropin alfa are likely to contribute to the differing pharmacokinetic and pharmacodynamic profiles observed in women and to influence their efficacy in therapeutic protocols for the treatment of infertility.http://www.endocrineconnections.com/content/6/5/297.fullfollicle-stimulating hormonefollitropin deltagonadotropin clearancerecombinant FSHFSH glycosylation |
| spellingShingle | Wolfgang Koechling Daniel Plaksin Glenn E Croston Janni V Jeppesen Kirsten T Macklon Claus Yding Andersen Comparative pharmacology of a new recombinant FSH expressed by a human cell line Endocrine Connections follicle-stimulating hormone follitropin delta gonadotropin clearance recombinant FSH FSH glycosylation |
| title | Comparative pharmacology of a new recombinant FSH expressed by a human cell line |
| title_full | Comparative pharmacology of a new recombinant FSH expressed by a human cell line |
| title_fullStr | Comparative pharmacology of a new recombinant FSH expressed by a human cell line |
| title_full_unstemmed | Comparative pharmacology of a new recombinant FSH expressed by a human cell line |
| title_short | Comparative pharmacology of a new recombinant FSH expressed by a human cell line |
| title_sort | comparative pharmacology of a new recombinant fsh expressed by a human cell line |
| topic | follicle-stimulating hormone follitropin delta gonadotropin clearance recombinant FSH FSH glycosylation |
| url | http://www.endocrineconnections.com/content/6/5/297.full |
| work_keys_str_mv | AT wolfgangkoechling comparativepharmacologyofanewrecombinantfshexpressedbyahumancellline AT danielplaksin comparativepharmacologyofanewrecombinantfshexpressedbyahumancellline AT glennecroston comparativepharmacologyofanewrecombinantfshexpressedbyahumancellline AT jannivjeppesen comparativepharmacologyofanewrecombinantfshexpressedbyahumancellline AT kirstentmacklon comparativepharmacologyofanewrecombinantfshexpressedbyahumancellline AT clausydingandersen comparativepharmacologyofanewrecombinantfshexpressedbyahumancellline |