The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development
This study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induce...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Turaz Bilim
2017-03-01
|
| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=231780 |
| _version_ | 1797327844713431040 |
|---|---|
| author | Songul Cuglan Nihat Ekinci Azibe Yildiz Zumrut Dogan Hilal Irmak Sapmaz Nigar Vardi Fatma Ozyalin Sinan Bakirci Mahmut Cay Evren Kose Yusuf Turkoz Davut Ozbag |
| author_facet | Songul Cuglan Nihat Ekinci Azibe Yildiz Zumrut Dogan Hilal Irmak Sapmaz Nigar Vardi Fatma Ozyalin Sinan Bakirci Mahmut Cay Evren Kose Yusuf Turkoz Davut Ozbag |
| author_sort | Songul Cuglan |
| collection | DOAJ |
| description | This study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically. [Med-Science 2017; 6(1.000): 73-80] |
| first_indexed | 2024-03-08T06:43:20Z |
| format | Article |
| id | doaj.art-694e02ba784b45baaf6fac20696e805a |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:43:20Z |
| publishDate | 2017-03-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-694e02ba784b45baaf6fac20696e805a2024-02-03T08:19:13ZengSociety of Turaz BilimMedicine Science2147-06342017-03-0161738010.5455/medscience.2016.05.8526231780The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney developmentSongul Cuglan0Nihat Ekinci1Azibe Yildiz2Zumrut Dogan3Hilal Irmak Sapmaz4Nigar Vardi5Fatma Ozyalin6Sinan Bakirci7Mahmut Cay8Evren Kose9Yusuf Turkoz10Davut Ozbag11Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey Department of Anatomy, Faculty of Medicine, Karabuk University, Karabuk, Turkey Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey. Department of Anatomy, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey Department of Anatomy, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey. Department of Anatomy, Faculty of Medicine, Duzce University, Duzce, Turkey. Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey. Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey. Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey. Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey.This study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically. [Med-Science 2017; 6(1.000): 73-80]http://www.ejmanager.com/fulltextpdf.php?mno=231780Formaldehydechrysinrat fetusesliverkidney |
| spellingShingle | Songul Cuglan Nihat Ekinci Azibe Yildiz Zumrut Dogan Hilal Irmak Sapmaz Nigar Vardi Fatma Ozyalin Sinan Bakirci Mahmut Cay Evren Kose Yusuf Turkoz Davut Ozbag The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development Medicine Science Formaldehyde chrysin rat fetuses liver kidney |
| title | The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development |
| title_full | The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development |
| title_fullStr | The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development |
| title_full_unstemmed | The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development |
| title_short | The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development |
| title_sort | role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development |
| topic | Formaldehyde chrysin rat fetuses liver kidney |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=231780 |
| work_keys_str_mv | AT songulcuglan theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT nihatekinci theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT azibeyildiz theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT zumrutdogan theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT hilalirmaksapmaz theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT nigarvardi theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT fatmaozyalin theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT sinanbakirci theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT mahmutcay theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT evrenkose theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT yusufturkoz theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT davutozbag theroleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT songulcuglan roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT nihatekinci roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT azibeyildiz roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT zumrutdogan roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT hilalirmaksapmaz roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT nigarvardi roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT fatmaozyalin roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT sinanbakirci roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT mahmutcay roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT evrenkose roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT yusufturkoz roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment AT davutozbag roleofchrysinagainstharmfuleffectsofformaldehydeexposureonthemorphologyofratfetusliverandkidneydevelopment |