Gene-editing techniques and their applications in livestock and beyond
Genetic modification enables modification of target genes or genome structure in livestock and experimental animals. These technologies have not only advanced bioscience but also improved agricultural productivity. To introduce a foreign transgene, the piggyBac transposon element/transposase system...
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Format: | Article |
Language: | English |
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Asian-Australasian Association of Animal Production Societies
2023-02-01
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Series: | Animal Bioscience |
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Online Access: | http://www.animbiosci.org/upload/pdf/ab-22-0383.pdf |
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author | Tae Sub Park |
author_facet | Tae Sub Park |
author_sort | Tae Sub Park |
collection | DOAJ |
description | Genetic modification enables modification of target genes or genome structure in livestock and experimental animals. These technologies have not only advanced bioscience but also improved agricultural productivity. To introduce a foreign transgene, the piggyBac transposon element/transposase system could be used for production of transgenic animals and specific target protein-expressing animal cells. In addition, the clustered regularly interspaced short palindromic repeat-CRISPR associated protein 9 (CRISPR-Cas9) system have been utilized to generate chickens with knockout of G0/G1 switch gene 2 (G0S2) and myostatin, which are related to lipid deposition and muscle growth, respectively. These experimental chickens could be the invaluable genetic resources to investigate the regulatory pathways and mechanisms of improvement of economic traits such as fat quantity and growth. The gene-edited animals could also be applicable to the livestock industry. |
first_indexed | 2024-04-10T17:07:18Z |
format | Article |
id | doaj.art-694f2b6e6c414c5ca8c0fe3d12aa4a5a |
institution | Directory Open Access Journal |
issn | 2765-0189 2765-0235 |
language | English |
last_indexed | 2024-04-10T17:07:18Z |
publishDate | 2023-02-01 |
publisher | Asian-Australasian Association of Animal Production Societies |
record_format | Article |
series | Animal Bioscience |
spelling | doaj.art-694f2b6e6c414c5ca8c0fe3d12aa4a5a2023-02-06T01:13:59ZengAsian-Australasian Association of Animal Production SocietiesAnimal Bioscience2765-01892765-02352023-02-0136233333810.5713/ab.22.038324993Gene-editing techniques and their applications in livestock and beyondTae Sub Park0 Graduate School of International Agricultural Technology and Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, KoreaGenetic modification enables modification of target genes or genome structure in livestock and experimental animals. These technologies have not only advanced bioscience but also improved agricultural productivity. To introduce a foreign transgene, the piggyBac transposon element/transposase system could be used for production of transgenic animals and specific target protein-expressing animal cells. In addition, the clustered regularly interspaced short palindromic repeat-CRISPR associated protein 9 (CRISPR-Cas9) system have been utilized to generate chickens with knockout of G0/G1 switch gene 2 (G0S2) and myostatin, which are related to lipid deposition and muscle growth, respectively. These experimental chickens could be the invaluable genetic resources to investigate the regulatory pathways and mechanisms of improvement of economic traits such as fat quantity and growth. The gene-edited animals could also be applicable to the livestock industry.http://www.animbiosci.org/upload/pdf/ab-22-0383.pdfchickencrispr-cas9economic traitsgene-editingtransgenesis |
spellingShingle | Tae Sub Park Gene-editing techniques and their applications in livestock and beyond Animal Bioscience chicken crispr-cas9 economic traits gene-editing transgenesis |
title | Gene-editing techniques and their applications in livestock and beyond |
title_full | Gene-editing techniques and their applications in livestock and beyond |
title_fullStr | Gene-editing techniques and their applications in livestock and beyond |
title_full_unstemmed | Gene-editing techniques and their applications in livestock and beyond |
title_short | Gene-editing techniques and their applications in livestock and beyond |
title_sort | gene editing techniques and their applications in livestock and beyond |
topic | chicken crispr-cas9 economic traits gene-editing transgenesis |
url | http://www.animbiosci.org/upload/pdf/ab-22-0383.pdf |
work_keys_str_mv | AT taesubpark geneeditingtechniquesandtheirapplicationsinlivestockandbeyond |