EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders
In vivo models are used in biomedical research to reproduce human disease and develop new drugs. However, they do not mimic the disease as it occurs in humans, and their use has failed to identify novel therapies effective for many highly prevalent non-communicable diseases, such as Alzheimer’s dise...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/12/17/2180 |
| _version_ | 1797496786434129920 |
|---|---|
| author | Laura Gribaldo Adelaide Dura |
| author_facet | Laura Gribaldo Adelaide Dura |
| author_sort | Laura Gribaldo |
| collection | DOAJ |
| description | In vivo models are used in biomedical research to reproduce human disease and develop new drugs. However, they do not mimic the disease as it occurs in humans, and their use has failed to identify novel therapies effective for many highly prevalent non-communicable diseases, such as Alzheimer’s disease. Indeed, the clinical failure rate in drug development remains very high, with an overall likelihood of approval from Phase I of about 9.6%. On the other hand, human-based models, advanced imaging techniques and human epidemiological studies may increase our understanding of disease aetiology and pathogenesis and enable the advance of safe and effective therapies. Particularly when human tissues are used, they may produce faster, cheaper results, more predictive for humans, whilst yielding greater comprehensions of human biochemical processes. A first effort to collect existing knowledge about non-animal models of highly prevalent human diseases was made by the Joint Research Centre of the European Commission. The final aim was to identify and share information on the capabilities and limits of human-based models at different levels: scientific communities, universities and secondary schools, national committees for animal welfare and the public at large. |
| first_indexed | 2024-03-10T03:08:32Z |
| format | Article |
| id | doaj.art-694fa1b35d764d9ba66e92055c775825 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T03:08:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-694fa1b35d764d9ba66e92055c7758252023-11-23T12:36:33ZengMDPI AGAnimals2076-26152022-08-011217218010.3390/ani12172180EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative DisordersLaura Gribaldo0Adelaide Dura1European Commission, Joint Research Centre (JRC), 21027 Ispra, ItalyEuropean Commission, Joint Research Centre (JRC), 21027 Ispra, ItalyIn vivo models are used in biomedical research to reproduce human disease and develop new drugs. However, they do not mimic the disease as it occurs in humans, and their use has failed to identify novel therapies effective for many highly prevalent non-communicable diseases, such as Alzheimer’s disease. Indeed, the clinical failure rate in drug development remains very high, with an overall likelihood of approval from Phase I of about 9.6%. On the other hand, human-based models, advanced imaging techniques and human epidemiological studies may increase our understanding of disease aetiology and pathogenesis and enable the advance of safe and effective therapies. Particularly when human tissues are used, they may produce faster, cheaper results, more predictive for humans, whilst yielding greater comprehensions of human biochemical processes. A first effort to collect existing knowledge about non-animal models of highly prevalent human diseases was made by the Joint Research Centre of the European Commission. The final aim was to identify and share information on the capabilities and limits of human-based models at different levels: scientific communities, universities and secondary schools, national committees for animal welfare and the public at large.https://www.mdpi.com/2076-2615/12/17/2180in vitro modelsbiomedical scienceshuman-based models |
| spellingShingle | Laura Gribaldo Adelaide Dura EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders Animals in vitro models biomedical sciences human-based models |
| title | EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders |
| title_full | EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders |
| title_fullStr | EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders |
| title_full_unstemmed | EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders |
| title_short | EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders |
| title_sort | eurl ecvam literature review series on advanced non animal models for respiratory diseases breast cancer and neurodegenerative disorders |
| topic | in vitro models biomedical sciences human-based models |
| url | https://www.mdpi.com/2076-2615/12/17/2180 |
| work_keys_str_mv | AT lauragribaldo eurlecvamliteraturereviewseriesonadvancednonanimalmodelsforrespiratorydiseasesbreastcancerandneurodegenerativedisorders AT adelaidedura eurlecvamliteraturereviewseriesonadvancednonanimalmodelsforrespiratorydiseasesbreastcancerandneurodegenerativedisorders |