Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs

Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs

Summary: B lymphocytes are exquisitely sensitive to fluctuations in nutrient signaling by the Rag GTPases, and 15% of follicular lymphomas (FLs) harbor activating mutations in RRAGC. Hence, a potential therapeutic approach against malignant B cells is to inhibit Rag GTPase signaling, but because suc...

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Bibliographic Details
Main Authors: Ana Ortega-Molina, Cristina Lebrero-Fernández, Alba Sanz, Nerea Deleyto-Seldas, Ana Belén Plata-Gómez, Camino Menéndez, Osvaldo Graña-Castro, Eduardo Caleiras, Alejo Efeyan
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
B cell lymphoma
germinal center
lymphocytes
mTOR
RRAGC
nutrient signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007701

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