The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019
Background: The incidence of early-onset colorectal cancer (CRC) diagnosed before age 50 has been increasing over the past decades. Hence, we examined the global, regional, and national burden of early-onset CRC and its risk factors from 1990 to 2019. Methods: Using data from the Global Burden of Di...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/14/3502 |
| _version_ | 1797433734514868224 |
|---|---|
| author | Wan-Jie Gu Jun-Peng Pei Jun Lyu Naohiko Akimoto Koichiro Haruki Shuji Ogino Chun-Dong Zhang |
| author_facet | Wan-Jie Gu Jun-Peng Pei Jun Lyu Naohiko Akimoto Koichiro Haruki Shuji Ogino Chun-Dong Zhang |
| author_sort | Wan-Jie Gu |
| collection | DOAJ |
| description | Background: The incidence of early-onset colorectal cancer (CRC) diagnosed before age 50 has been increasing over the past decades. Hence, we examined the global, regional, and national burden of early-onset CRC and its risk factors from 1990 to 2019. Methods: Using data from the Global Burden of Disease (GBD) Study 2019, we reported the incidence, deaths, and disability-adjusted life-years (DALYs) attributable to the risk factors of early-onset CRC. All estimates were reported with 95% uncertainty intervals (UIs). Results: The global numbers of early-onset CRC for incidence, deaths, and DALYs in 2019 were 225,736 (95% UI, 207,658 to 246,756), 86,545 (80,162 to 93,431), and 4,259,922 (3,942,849 to 4,590,979), respectively. Despite large variations at the regional and national levels, the global incidence rate, death rate, and DALY rate increased from 1990 to 2019. Diets low in milk, diets low in calcium, and alcohol use were the leading risk factors in 2019. From 1990 to 2019, a high body mass index and high fasting plasma glucose ranked remarkably higher among males and females, while smoking and diets low in fiber ranked lower among both sexes, with a more profound change among females. Conclusions: Despite large variations in regional and national levels, the global incidence rate, death rate, and DALY rate increased during the past three decades. These findings may provide policymakers with an accurate quantification of the burden of early-onset CRC and targeted identification of those most at risk to mitigate the burden of early-onset CRC. |
| first_indexed | 2024-03-09T10:21:14Z |
| format | Article |
| id | doaj.art-69503d25f5ca407297d25bdf23443d17 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T10:21:14Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-69503d25f5ca407297d25bdf23443d172023-12-01T21:59:47ZengMDPI AGCancers2072-66942022-07-011414350210.3390/cancers14143502The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019Wan-Jie Gu0Jun-Peng Pei1Jun Lyu2Naohiko Akimoto3Koichiro Haruki4Shuji Ogino5Chun-Dong Zhang6Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100142, ChinaDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USAProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USAProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, JapanBackground: The incidence of early-onset colorectal cancer (CRC) diagnosed before age 50 has been increasing over the past decades. Hence, we examined the global, regional, and national burden of early-onset CRC and its risk factors from 1990 to 2019. Methods: Using data from the Global Burden of Disease (GBD) Study 2019, we reported the incidence, deaths, and disability-adjusted life-years (DALYs) attributable to the risk factors of early-onset CRC. All estimates were reported with 95% uncertainty intervals (UIs). Results: The global numbers of early-onset CRC for incidence, deaths, and DALYs in 2019 were 225,736 (95% UI, 207,658 to 246,756), 86,545 (80,162 to 93,431), and 4,259,922 (3,942,849 to 4,590,979), respectively. Despite large variations at the regional and national levels, the global incidence rate, death rate, and DALY rate increased from 1990 to 2019. Diets low in milk, diets low in calcium, and alcohol use were the leading risk factors in 2019. From 1990 to 2019, a high body mass index and high fasting plasma glucose ranked remarkably higher among males and females, while smoking and diets low in fiber ranked lower among both sexes, with a more profound change among females. Conclusions: Despite large variations in regional and national levels, the global incidence rate, death rate, and DALY rate increased during the past three decades. These findings may provide policymakers with an accurate quantification of the burden of early-onset CRC and targeted identification of those most at risk to mitigate the burden of early-onset CRC.https://www.mdpi.com/2072-6694/14/14/3502colorectal carcinomaglobal burden of diseaseincidencemortalityyoung-onset |
| spellingShingle | Wan-Jie Gu Jun-Peng Pei Jun Lyu Naohiko Akimoto Koichiro Haruki Shuji Ogino Chun-Dong Zhang The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 Cancers colorectal carcinoma global burden of disease incidence mortality young-onset |
| title | The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 |
| title_full | The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 |
| title_fullStr | The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 |
| title_full_unstemmed | The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 |
| title_short | The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 |
| title_sort | burden of early onset colorectal cancer and its risk factors from 1990 to 2019 a systematic analysis for the global burden of disease study 2019 |
| topic | colorectal carcinoma global burden of disease incidence mortality young-onset |
| url | https://www.mdpi.com/2072-6694/14/14/3502 |
| work_keys_str_mv | AT wanjiegu theburdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT junpengpei theburdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT junlyu theburdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT naohikoakimoto theburdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT koichiroharuki theburdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT shujiogino theburdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT chundongzhang theburdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT wanjiegu burdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT junpengpei burdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT junlyu burdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT naohikoakimoto burdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT koichiroharuki burdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT shujiogino burdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 AT chundongzhang burdenofearlyonsetcolorectalcanceranditsriskfactorsfrom1990to2019asystematicanalysisfortheglobalburdenofdiseasestudy2019 |