TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway
ABSTRACTCritical-size defects (CSDs) are challenging oral clinical issues that need to be solved. Adipose-derived mesenchymal stem cells (ADSCs) and gene therapy offer a new target to solve these issues. Consequently, ADSCs attract more and more attention because of advantages such as easy obtainabi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Adipocyte |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21623945.2023.2193280 |
| _version_ | 1827380607006539776 |
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| author | Xiang-Dong Liu Jian Zheng Shuang Song Zi-Jun Chen Yu-Xi Wang Si-Jia Zhang Guan-Hua Zhang Qun Lu Ying-Liang Song |
| author_facet | Xiang-Dong Liu Jian Zheng Shuang Song Zi-Jun Chen Yu-Xi Wang Si-Jia Zhang Guan-Hua Zhang Qun Lu Ying-Liang Song |
| author_sort | Xiang-Dong Liu |
| collection | DOAJ |
| description | ABSTRACTCritical-size defects (CSDs) are challenging oral clinical issues that need to be solved. Adipose-derived mesenchymal stem cells (ADSCs) and gene therapy offer a new target to solve these issues. Consequently, ADSCs attract more and more attention because of advantages such as easy obtainability and no ethical concerns. TNF receptor-associated factor 6 (TRAF6) is a significant binding protein both of tumour necrosis factor superfamily and of the toll/interleukin-1 receptor superfamily. Evidence is accumulating that TRAF6 inhibited osteoclast formation and promoted the proliferation of multiple myeloma cell lines and bone resorption. Here, we reported that overexpression of TRAF6 enhanced the proliferation, migration and osteogenesis of ADSCs through Raf-Erk-Merk-Hif1a pathway. Cell sheet of ADSCs combined with TRAF6 accelerated the healing of CSDs. In a word, TRAF6 enhanced osteogenesis, migration and proliferation through Raf-Erk-Merk-Hif1a pathway. |
| first_indexed | 2024-03-08T13:37:23Z |
| format | Article |
| id | doaj.art-69517f3a19614e2b9ba8f88a0e5b1e3b |
| institution | Directory Open Access Journal |
| issn | 2162-3945 2162-397X |
| language | English |
| last_indexed | 2024-03-08T13:37:23Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj.art-69517f3a19614e2b9ba8f88a0e5b1e3b2024-01-16T15:50:36ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2023-12-0112110.1080/21623945.2023.2193280TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathwayXiang-Dong Liu0Jian Zheng1Shuang Song2Zi-Jun Chen3Yu-Xi Wang4Si-Jia Zhang5Guan-Hua Zhang6Qun Lu7Ying-Liang Song8State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaDepartment of Implant Dentistry, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi’an, P.R. ChinaABSTRACTCritical-size defects (CSDs) are challenging oral clinical issues that need to be solved. Adipose-derived mesenchymal stem cells (ADSCs) and gene therapy offer a new target to solve these issues. Consequently, ADSCs attract more and more attention because of advantages such as easy obtainability and no ethical concerns. TNF receptor-associated factor 6 (TRAF6) is a significant binding protein both of tumour necrosis factor superfamily and of the toll/interleukin-1 receptor superfamily. Evidence is accumulating that TRAF6 inhibited osteoclast formation and promoted the proliferation of multiple myeloma cell lines and bone resorption. Here, we reported that overexpression of TRAF6 enhanced the proliferation, migration and osteogenesis of ADSCs through Raf-Erk-Merk-Hif1a pathway. Cell sheet of ADSCs combined with TRAF6 accelerated the healing of CSDs. In a word, TRAF6 enhanced osteogenesis, migration and proliferation through Raf-Erk-Merk-Hif1a pathway.https://www.tandfonline.com/doi/10.1080/21623945.2023.2193280ADSCsTRAF6Hif1aOsteogenesis |
| spellingShingle | Xiang-Dong Liu Jian Zheng Shuang Song Zi-Jun Chen Yu-Xi Wang Si-Jia Zhang Guan-Hua Zhang Qun Lu Ying-Liang Song TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway Adipocyte ADSCs TRAF6 Hif1a Osteogenesis |
| title | TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway |
| title_full | TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway |
| title_fullStr | TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway |
| title_full_unstemmed | TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway |
| title_short | TRAF6 promotes osteogenesis in ADSCs through Raf-Erk-Merk-Hif1-a pathway |
| title_sort | traf6 promotes osteogenesis in adscs through raf erk merk hif1 a pathway |
| topic | ADSCs TRAF6 Hif1a Osteogenesis |
| url | https://www.tandfonline.com/doi/10.1080/21623945.2023.2193280 |
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