A novel method for heterocyclic amide–thioamide transformations
In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2017-01-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.13.20 |
| _version_ | 1828925611208343552 |
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| author | Walid Fathalla Ibrahim A. I. Ali Pavel Pazdera |
| author_facet | Walid Fathalla Ibrahim A. I. Ali Pavel Pazdera |
| author_sort | Walid Fathalla |
| collection | DOAJ |
| description | In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields. |
| first_indexed | 2024-12-13T23:17:48Z |
| format | Article |
| id | doaj.art-6952359699f043f387d8f03a85d3789b |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-13T23:17:48Z |
| publishDate | 2017-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-6952359699f043f387d8f03a85d3789b2022-12-21T23:27:53ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972017-01-0113117418110.3762/bjoc.13.201860-5397-13-20A novel method for heterocyclic amide–thioamide transformationsWalid Fathalla0Ibrahim A. I. Ali1Pavel Pazdera2Physics and Math. Engineering Dept., Faculty of Engineering, Port-Said University, Port Said, EgyptDepartment of Chemistry, Faculty of Science, Suez Canal University, Ismailia, EgyptCentre for Syntheses at Sustainable Conditions and Their Management, Faculty of Science, Masaryk University, Brno, Czech RepublicIn this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields.https://doi.org/10.3762/bjoc.13.20heterocyclic amidesheterocyclic thioamidesN-cyclohexyl dithiocarbamate cyclohexylammonium saltnovel thiating agentthiation |
| spellingShingle | Walid Fathalla Ibrahim A. I. Ali Pavel Pazdera A novel method for heterocyclic amide–thioamide transformations Beilstein Journal of Organic Chemistry heterocyclic amides heterocyclic thioamides N-cyclohexyl dithiocarbamate cyclohexylammonium salt novel thiating agent thiation |
| title | A novel method for heterocyclic amide–thioamide transformations |
| title_full | A novel method for heterocyclic amide–thioamide transformations |
| title_fullStr | A novel method for heterocyclic amide–thioamide transformations |
| title_full_unstemmed | A novel method for heterocyclic amide–thioamide transformations |
| title_short | A novel method for heterocyclic amide–thioamide transformations |
| title_sort | novel method for heterocyclic amide thioamide transformations |
| topic | heterocyclic amides heterocyclic thioamides N-cyclohexyl dithiocarbamate cyclohexylammonium salt novel thiating agent thiation |
| url | https://doi.org/10.3762/bjoc.13.20 |
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