Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome
We investigated the effect of weight loss, independent of change in diet composition, on HDL and apoAI metabolism in men with metabolic syndrome (MetS). Subjects (19 men with MetS [NCEP-ATPIII]) were fed an isoenergetic Mediterranean-style diet for 5 weeks (all foods provided). Participants then und...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520417778 |
| _version_ | 1819077308616540160 |
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| author | Caroline Richard Patrick Couture Sophie Desroches Alice H. Lichtenstein Benoît Lamarche |
| author_facet | Caroline Richard Patrick Couture Sophie Desroches Alice H. Lichtenstein Benoît Lamarche |
| author_sort | Caroline Richard |
| collection | DOAJ |
| description | We investigated the effect of weight loss, independent of change in diet composition, on HDL and apoAI metabolism in men with metabolic syndrome (MetS). Subjects (19 men with MetS [NCEP-ATPIII]) were fed an isoenergetic Mediterranean-style diet for 5 weeks (all foods provided). Participants then underwent a 20-week free-living period during which they were counseled to restrict energy intake, after which they were again fed an isoenergetic Mediterranean-style diet for 5 weeks. At the end of the two controlled diets, participants received a single bolus of [5,5,5-2H3] L-leucine, and fasting blood samples were collected over a 96 h period. ApoAI kinetic was assessed using multicompartmental modeling of the tracer enrichment data. Participants achieved a 9.1 ± 2.8% reduction in body weight (P < 0.001). Weight loss resulted in an increase in plasma HDL-cholesterol (HDL-C) concentrations of 6.0% (P = 0.059) and HDL3-C of 7.9% (P = 0.045), attributable to a reduction in apoAI fractional catabolic rate (−7.8%; P = 0.046) with no change in apoAI production rate (2.2%; P = 0.58). These data indicate that weight loss, independent of variation in diet composition, increases plasma HDL primarily by delaying the catabolism of apoAI. |
| first_indexed | 2024-12-21T18:55:08Z |
| format | Article |
| id | doaj.art-69538aa0a19745aaaf5c788697537623 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-21T18:55:08Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-69538aa0a19745aaaf5c7886975376232022-12-21T18:53:39ZengElsevierJournal of Lipid Research0022-22752013-01-01541232237Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndromeCaroline Richard0Patrick Couture1Sophie Desroches2Alice H. Lichtenstein3Benoît Lamarche4Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada, G1V 0A6Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada, G1V 0A6; Lipid Research Center, CHUQ Research Center, Quebec, Canada; andInstitute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada, G1V 0A6Cardiovascular Nutrition Laboratory, Tufts University, Boston, MA 02111To whom correspondence should be addressed. e-mail: Benoit.Lamarche@inaf.ulaval.ca.; Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada, G1V 0A6; To whom correspondence should be addressed. e-mail: Benoit.Lamarche@inaf.ulaval.ca.We investigated the effect of weight loss, independent of change in diet composition, on HDL and apoAI metabolism in men with metabolic syndrome (MetS). Subjects (19 men with MetS [NCEP-ATPIII]) were fed an isoenergetic Mediterranean-style diet for 5 weeks (all foods provided). Participants then underwent a 20-week free-living period during which they were counseled to restrict energy intake, after which they were again fed an isoenergetic Mediterranean-style diet for 5 weeks. At the end of the two controlled diets, participants received a single bolus of [5,5,5-2H3] L-leucine, and fasting blood samples were collected over a 96 h period. ApoAI kinetic was assessed using multicompartmental modeling of the tracer enrichment data. Participants achieved a 9.1 ± 2.8% reduction in body weight (P < 0.001). Weight loss resulted in an increase in plasma HDL-cholesterol (HDL-C) concentrations of 6.0% (P = 0.059) and HDL3-C of 7.9% (P = 0.045), attributable to a reduction in apoAI fractional catabolic rate (−7.8%; P = 0.046) with no change in apoAI production rate (2.2%; P = 0.58). These data indicate that weight loss, independent of variation in diet composition, increases plasma HDL primarily by delaying the catabolism of apoAI.http://www.sciencedirect.com/science/article/pii/S0022227520417778apolipoproteinskineticshigh density lipoprotein metabolismobesity |
| spellingShingle | Caroline Richard Patrick Couture Sophie Desroches Alice H. Lichtenstein Benoît Lamarche Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome Journal of Lipid Research apolipoproteins kinetics high density lipoprotein metabolism obesity |
| title | Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome |
| title_full | Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome |
| title_fullStr | Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome |
| title_full_unstemmed | Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome |
| title_short | Effect of weight loss, independent of change in diet composition, on apolipoprotein AI kinetic in men with metabolic syndrome |
| title_sort | effect of weight loss independent of change in diet composition on apolipoprotein ai kinetic in men with metabolic syndrome |
| topic | apolipoproteins kinetics high density lipoprotein metabolism obesity |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520417778 |
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