Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case
We report the CT, surgical and histopathologic findings of a rare case of Hepatic Angiosarcoma (HAS) diagnosed in a 85-year old women 65 years after Thorotrast (Th²³²) exposure for angiography. At the early arterial phase of dynamic MDCT, peripheral curvilinear and central nodular puddling of contra...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2014-05-01
|
| Series: | Journal of the Belgian Society of Radiology |
| Subjects: | |
| Online Access: | https://www.jbsr.be/articles/85 |
| _version_ | 1819077428729872384 |
|---|---|
| author | B Coulier F Pierard I Gielen Ph Maldague |
| author_facet | B Coulier F Pierard I Gielen Ph Maldague |
| author_sort | B Coulier |
| collection | DOAJ |
| description | We report the CT, surgical and histopathologic findings of a rare case of Hepatic Angiosarcoma (HAS) diagnosed in a 85-year old women 65 years after Thorotrast (Th²³²) exposure for angiography. At the early arterial phase of dynamic MDCT, peripheral curvilinear and central nodular puddling of contrast produced in the 8 cm tumor. Then progressive contrast filling of the tumor was observed on the delayed scans. Associated pathognomonic signs related to previous Th²³² exposure were also found comprising diffuse intrahepatic reticular bands of calcifications, numerous calcified epigastric lymph nodes and a calcified shrunken spleen. Emergency laparotomy was performed because of associated hemoperitoneum. With a delay of 65 years after Thorotrast exposure, this historical case probably represents, to our knowledge, the most delayed presentation of Th²³² related HAS ever published. |
| first_indexed | 2024-12-21T18:57:03Z |
| format | Article |
| id | doaj.art-69542b3640454210a54b9da8b3347d09 |
| institution | Directory Open Access Journal |
| issn | 2514-8281 |
| language | English |
| last_indexed | 2024-12-21T18:57:03Z |
| publishDate | 2014-05-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of the Belgian Society of Radiology |
| spelling | doaj.art-69542b3640454210a54b9da8b3347d092022-12-21T18:53:35ZengUbiquity PressJournal of the Belgian Society of Radiology2514-82812014-05-0197425425810.5334/jbr-btr.8585Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical caseB Coulier0F Pierard1I Gielen2Ph Maldague3Department of Diagnostic Radiology Loverval, BelgiumDepartment of Visceral Surgery, Loverval, BelgiumInstitute of Pathology and Genetics, Loverval, BelgiumDepartment of Gastroenterology, Clinique St Luc, Bouge (Namur)We report the CT, surgical and histopathologic findings of a rare case of Hepatic Angiosarcoma (HAS) diagnosed in a 85-year old women 65 years after Thorotrast (Th²³²) exposure for angiography. At the early arterial phase of dynamic MDCT, peripheral curvilinear and central nodular puddling of contrast produced in the 8 cm tumor. Then progressive contrast filling of the tumor was observed on the delayed scans. Associated pathognomonic signs related to previous Th²³² exposure were also found comprising diffuse intrahepatic reticular bands of calcifications, numerous calcified epigastric lymph nodes and a calcified shrunken spleen. Emergency laparotomy was performed because of associated hemoperitoneum. With a delay of 65 years after Thorotrast exposure, this historical case probably represents, to our knowledge, the most delayed presentation of Th²³² related HAS ever published.https://www.jbsr.be/articles/85Liver neoplasms – Thorium oxide |
| spellingShingle | B Coulier F Pierard I Gielen Ph Maldague Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case Journal of the Belgian Society of Radiology Liver neoplasms – Thorium oxide |
| title | Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case |
| title_full | Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case |
| title_fullStr | Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case |
| title_full_unstemmed | Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case |
| title_short | Hepatic angiosarcoma occurring 65 years after thorium dioxide (Thorostrast) exposure: imaging, surgical and histopathologic findings of a historical case |
| title_sort | hepatic angiosarcoma occurring 65 years after thorium dioxide thorostrast exposure imaging surgical and histopathologic findings of a historical case |
| topic | Liver neoplasms – Thorium oxide |
| url | https://www.jbsr.be/articles/85 |
| work_keys_str_mv | AT bcoulier hepaticangiosarcomaoccurring65yearsafterthoriumdioxidethorostrastexposureimagingsurgicalandhistopathologicfindingsofahistoricalcase AT fpierard hepaticangiosarcomaoccurring65yearsafterthoriumdioxidethorostrastexposureimagingsurgicalandhistopathologicfindingsofahistoricalcase AT igielen hepaticangiosarcomaoccurring65yearsafterthoriumdioxidethorostrastexposureimagingsurgicalandhistopathologicfindingsofahistoricalcase AT phmaldague hepaticangiosarcomaoccurring65yearsafterthoriumdioxidethorostrastexposureimagingsurgicalandhistopathologicfindingsofahistoricalcase |