Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trial
Objective: This trial was to examine the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive function in older patients who underwent thoracoscopic pulmonary resection. Methods: This was a prospective, randomized, double-blind, placebo-controlled study. 128 pat...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023065945 |
| _version_ | 1797669903713435648 |
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| author | Fei Guo Ruili Han Li Sun Lanlan Zheng Yanzheng Wang Yuting Yan Chen Liu Yuan Qin Chen Yuan Shuang Wang Xude Sun Changjun Gao |
| author_facet | Fei Guo Ruili Han Li Sun Lanlan Zheng Yanzheng Wang Yuting Yan Chen Liu Yuan Qin Chen Yuan Shuang Wang Xude Sun Changjun Gao |
| author_sort | Fei Guo |
| collection | DOAJ |
| description | Objective: This trial was to examine the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive function in older patients who underwent thoracoscopic pulmonary resection. Methods: This was a prospective, randomized, double-blind, placebo-controlled study. 128 patients scheduled for surgery were randomly assigned to the TEAS group and sham-TEAS group. A standardized intervention of TEAS or sham-TEAS on the acupoints of Baihui (DU20) and bilateral Neiguan (PC6), Hegu (LI4), and Zusanli (ST36) from 30 min before anesthesia induction until the end of the surgery, combined with a general anesthetic protocol performed in the two groups respectively. The primary outcome was the incidence of postoperative cognitive dysfunction (POCD) assessed via the Montreal Cognitive Assessment (MoCA) scale at each time point. The secondary outcomes included the results of the Mini-Mental State Examination (MMSE) score, the Numerical Rating Scale (NRS) on pain and sleep, the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30), and a chronic pain questionnaire at relative time points. Results: Participants who completed the 12-month trial of the two groups were well-matched in baseline demographic and clinical parameters. At postoperative day 1, day 7, and day 30 time points, the incidence of POCD in the sham-TEAS group was always significantly higher than in the TEAS group (65.4% vs 20%, 43.6% vs 7.3%, 40% vs 3.6%, all P < 0.001). Also, the TEAS group showed better scores of MMSE, sleep, and pain compared with the sham-TEAS group (all P < 0.001). At 6 and 12 months points, the global health scores of the TEAS group were still significantly higher than the sham-TEAS group, and the prevalence of chronic pain was significantly lower than the sham-TEAS group (all P < 0.05). Conclusion: TEAS could effectively improve the postoperative cognitive function and long-term life quality of geriatric patients with lung cancer. |
| first_indexed | 2024-03-11T20:51:37Z |
| format | Article |
| id | doaj.art-695591d14cb54fc8b957c04c9154f837 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:51:37Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj.art-695591d14cb54fc8b957c04c9154f8372023-10-01T05:59:25ZengElsevierHeliyon2405-84402023-09-0199e19386Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trialFei Guo0Ruili Han1Li Sun2Lanlan Zheng3Yanzheng Wang4Yuting Yan5Chen Liu6Yuan Qin7Chen Yuan8Shuang Wang9Xude Sun10Changjun Gao11Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaDepartment of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaCorresponding author. Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710038, People's Republic of China.; Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaCorresponding author. Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710038, People's Republic of China.; Department of Anesthesiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of ChinaObjective: This trial was to examine the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative cognitive function in older patients who underwent thoracoscopic pulmonary resection. Methods: This was a prospective, randomized, double-blind, placebo-controlled study. 128 patients scheduled for surgery were randomly assigned to the TEAS group and sham-TEAS group. A standardized intervention of TEAS or sham-TEAS on the acupoints of Baihui (DU20) and bilateral Neiguan (PC6), Hegu (LI4), and Zusanli (ST36) from 30 min before anesthesia induction until the end of the surgery, combined with a general anesthetic protocol performed in the two groups respectively. The primary outcome was the incidence of postoperative cognitive dysfunction (POCD) assessed via the Montreal Cognitive Assessment (MoCA) scale at each time point. The secondary outcomes included the results of the Mini-Mental State Examination (MMSE) score, the Numerical Rating Scale (NRS) on pain and sleep, the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30), and a chronic pain questionnaire at relative time points. Results: Participants who completed the 12-month trial of the two groups were well-matched in baseline demographic and clinical parameters. At postoperative day 1, day 7, and day 30 time points, the incidence of POCD in the sham-TEAS group was always significantly higher than in the TEAS group (65.4% vs 20%, 43.6% vs 7.3%, 40% vs 3.6%, all P < 0.001). Also, the TEAS group showed better scores of MMSE, sleep, and pain compared with the sham-TEAS group (all P < 0.001). At 6 and 12 months points, the global health scores of the TEAS group were still significantly higher than the sham-TEAS group, and the prevalence of chronic pain was significantly lower than the sham-TEAS group (all P < 0.05). Conclusion: TEAS could effectively improve the postoperative cognitive function and long-term life quality of geriatric patients with lung cancer.http://www.sciencedirect.com/science/article/pii/S2405844023065945Transcutaneous electrical acupoint stimulation(TEAS)Postoperative cognitive dysfunction(POCD)Quality of lifeLung cancerOlder patients |
| spellingShingle | Fei Guo Ruili Han Li Sun Lanlan Zheng Yanzheng Wang Yuting Yan Chen Liu Yuan Qin Chen Yuan Shuang Wang Xude Sun Changjun Gao Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trial Heliyon Transcutaneous electrical acupoint stimulation(TEAS) Postoperative cognitive dysfunction(POCD) Quality of life Lung cancer Older patients |
| title | Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trial |
| title_full | Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trial |
| title_fullStr | Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trial |
| title_short | Effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer: A randomized, double-blind, placebo-controlled trial |
| title_sort | effect of transcutaneous electrical acupoint stimulation on postoperative cognitive function in older patients with lung cancer a randomized double blind placebo controlled trial |
| topic | Transcutaneous electrical acupoint stimulation(TEAS) Postoperative cognitive dysfunction(POCD) Quality of life Lung cancer Older patients |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023065945 |
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