Charge Shielding of PIP2 by Cations Regulates Enzyme Activity of Phospholipase C.

Charge Shielding of PIP2 by Cations Regulates Enzyme Activity of Phospholipase C.

Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) of the plasma membrane by phospholipase C (PLC) generates two critical second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. For the enzymatic reaction, PIP2 binds to positively charged amino acids in the pleckstrin homology do...

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Bibliographic Details
Main Authors: Jong Bae Seo, Seung-Ryoung Jung, Weigang Huang, Qisheng Zhang, Duk-Su Koh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4676720?pdf=render

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