Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern Sudan
<p>Abstract</p> <p>Background</p> <p>Maternal immunity is thought to play a major role in the increased susceptibility of pregnant women to <it>Plasmodium falciparum </it>malaria. Few studies exist on immunohistochemical characterization of the placental inf...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-09-01
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| Series: | Diagnostic Pathology |
| Online Access: | http://www.diagnosticpathology.org/content/6/1/83 |
| _version_ | 1819030885740052480 |
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| author | Adam Gamal K Mohmmed Ahmed A Mohammed Amal H Salih Magdi M Elbashir Mustafa I Adam Ishag |
| author_facet | Adam Gamal K Mohmmed Ahmed A Mohammed Amal H Salih Magdi M Elbashir Mustafa I Adam Ishag |
| author_sort | Adam Gamal K |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Maternal immunity is thought to play a major role in the increased susceptibility of pregnant women to <it>Plasmodium falciparum </it>malaria. Few studies exist on immunohistochemical characterization of the placental inflammatory infiltrate. The current study was conducted in Gadarif hospital in an area characterized by unstable malaria transmission in eastern Sudan.</p> <p>Method</p> <p>Ninety three placentae were investigated for malaria histological changes and immunohistochemical study for monocytes and macrophages (CD68).</p> <p>Results</p> <p>While 1(1.1%), 2(2.2%) and 20(21.5%) of the 93 placentae had acute, chronic and past malaria infections, 70(75.2%) had no malaria infections. Monocytes and macrophage (CD 68) were detected in 29 (31.2%) of these 93 placentae. Significantly higher rate of monocytes and macrophage were detected in placentae with malaria infections [11/23 (47.8%) vs. 18/70 (25.7%); <it>P </it>= 0.047] especially in placentae with past malaria infections. Placental malaria infections and monocytes and macrophages cells infiltration were not different between primiparae and multiparae. There was no significant difference in the birth weight between the women with placental malaria infections/monocytes and macrophages cells infiltration and those who had no placental malaria infections/cellular infiltrations.</p> <p>Conclusion</p> <p>Significantly higher rate of monocytes and macrophage were detected in placentae with malaria infections. Neither placental malaria infections nor cellular infiltrates were associated with parity or lead to reduction of birth weight.</p> |
| first_indexed | 2024-12-21T06:37:16Z |
| format | Article |
| id | doaj.art-695864c474e4492797c6771946608e5a |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-21T06:37:16Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-695864c474e4492797c6771946608e5a2022-12-21T19:12:49ZengBMCDiagnostic Pathology1746-15962011-09-01618310.1186/1746-1596-6-83Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern SudanAdam Gamal KMohmmed Ahmed AMohammed Amal HSalih Magdi MElbashir Mustafa IAdam Ishag<p>Abstract</p> <p>Background</p> <p>Maternal immunity is thought to play a major role in the increased susceptibility of pregnant women to <it>Plasmodium falciparum </it>malaria. Few studies exist on immunohistochemical characterization of the placental inflammatory infiltrate. The current study was conducted in Gadarif hospital in an area characterized by unstable malaria transmission in eastern Sudan.</p> <p>Method</p> <p>Ninety three placentae were investigated for malaria histological changes and immunohistochemical study for monocytes and macrophages (CD68).</p> <p>Results</p> <p>While 1(1.1%), 2(2.2%) and 20(21.5%) of the 93 placentae had acute, chronic and past malaria infections, 70(75.2%) had no malaria infections. Monocytes and macrophage (CD 68) were detected in 29 (31.2%) of these 93 placentae. Significantly higher rate of monocytes and macrophage were detected in placentae with malaria infections [11/23 (47.8%) vs. 18/70 (25.7%); <it>P </it>= 0.047] especially in placentae with past malaria infections. Placental malaria infections and monocytes and macrophages cells infiltration were not different between primiparae and multiparae. There was no significant difference in the birth weight between the women with placental malaria infections/monocytes and macrophages cells infiltration and those who had no placental malaria infections/cellular infiltrations.</p> <p>Conclusion</p> <p>Significantly higher rate of monocytes and macrophage were detected in placentae with malaria infections. Neither placental malaria infections nor cellular infiltrates were associated with parity or lead to reduction of birth weight.</p>http://www.diagnosticpathology.org/content/6/1/83 |
| spellingShingle | Adam Gamal K Mohmmed Ahmed A Mohammed Amal H Salih Magdi M Elbashir Mustafa I Adam Ishag Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern Sudan Diagnostic Pathology |
| title | Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern Sudan |
| title_full | Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern Sudan |
| title_fullStr | Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern Sudan |
| title_full_unstemmed | Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern Sudan |
| title_short | Monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern Sudan |
| title_sort | monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern sudan |
| url | http://www.diagnosticpathology.org/content/6/1/83 |
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